肱动脉内皮依赖性舒张功能和妊娠期糖尿病妇女产后认知功能的关系分析  

Relationship between endothelium-dependent diastolic function of brachial artery and postnatal cognitive function in women with gestational diabetes

作　　者：乔丽娟 张会乐 吴乐策 QIAO Li-juan;ZHANG Hui-le;WU Le-ce(Department of Obstetrics and Gynecology,the Third People’s Hospital of Henan Province,Zhengzhou 450002,China)

机构地区：[1]河南省直第三人民医院妇产科,郑州450002

出　　处：《医药论坛杂志》2022年第11期65-68,共4页Journal of Medical Forum

摘　　要：目的分析肱动脉内皮依赖性舒张功能和妊娠期糖尿病妇女产后认知功能的关系。方法选取2018年1月—2020年1月河南省直第三人民医院收治的188例妊娠期糖尿病妇女为研究对象,所有患者产后均使用简易智能精神状态量表(MMSE)评估认知功能,依据MMSE评分将其分为认知功能障碍组(n=45)和对照组(n=143)。比较两组产妇的肱动脉血管内皮依赖性舒张变化率(FMD)和内皮非依赖性舒张变化率(NID),并单因素和Logistic多因素分析妊娠糖尿病妇女产后认知功能障碍的相关因素,Spearman相关分析肱动脉内皮依赖性舒张功能与妊娠期糖尿病妇女产后认知功能障碍的相关性。结果认知功能障碍组产妇的FMD和NID水平均低于对照组产妇,差异具有统计学意义(P<0.05)。单因素分析结果显示,认知功能障碍组与对照组产妇的BMI、受教育年限、C肽、FMD、NID水平间差异具有统计学意义(P<0.05)。Logistic多因素分析结果显示,高BMI、低受教育年限、低FMD、低NID水平为妊娠糖尿病妇女产后认知功能障碍的危险因素(P<0.05)。Spearman相关分析结果显示,妊娠糖尿病妇女的MMSE分数与FMD、NID呈现正相关趋势(r=0.503,P=0.038;r=0.530,P=0.005)。结论高BMI、低受教育年限、低FMD、低NID水平为妊娠期糖尿病妇女产后认知功能障碍的危险因素,临床中应对上述患者加强监控,以降低产后认知功能的发生率。Objective To analyze the relationship between endothelium-dependent diastolic function of the brachial artery and postnatal cognitive function in women with gestational diabetes mellitus.Methods Totally 188 women with gestational diabetes admitted to our hospital from January 2018 to January 2020 were enrolled.All patients were assessed for cognitive function using the Simple Intelligence Mental Status Scale(MMSE)after childbirth.Cognitive dysfunction group(n=45)and control group(n=143).Comparison of brachial artery endothelium-dependent diastolic change rate(FMD)and endothelium-independent diastolic change rate(NID)in two groups,and single factor and Logistic multivariate analysis of factors related to postpartum cognitive dysfunction in gestational diabetes women,Spearman correlation analysis of the correlation between brachial artery endothelium-dependent diastolic function and postpartum cognitive dysfunction in women with diabetes mellitus.Results The FMD and NID levels in the cognitive dysfunction group were lower than those in the control group,and the difference was statistically significant(P<0.05).Univariate analysis showed that the differences in BMI,years of education,C-peptide,FMD,and NID between the cognitive dysfunction group and the control group were statistically significant(P<0.05).Logistic multivariate analysis showed that high BMI,low years of education,low FMD,and low NID were risk factors for postpartum cognitive dysfunction in women with gestational diabetes(P<0.05).Spearman correlation analysis showed that the MMSE scores of pregnant women with diabetes were positively correlated with FMD and NID(r=0.503,P=0.038;r=0.530,P=0.005).Conclusion High BMI,low years of education,low FMD,and low NID levels are risk factors for postpartum cognitive dysfunction in women with gestational diabetes.The above-mentioned patients should be monitored in clinical to reduce the incidence of postpartum cognitive function.

关 键 词：妊娠期糖尿病 认知功能 内皮依赖性舒张变化率 内皮非依赖性舒张变化率 

分 类 号：R714.256[医药卫生—妇产科学]