阿尔茨海默症的临床治疗和天然来源潜在药物的研究进展  

Research progress in clinical treatment of Alzheimer’s disease and potential drugs from natural products

作　　者：张平 季晖[2] 胡庆华[2] ZHANG Ping;JI Hui;HU Qing-hua(Zhongshan Vocational College,Nanjing 210049,China;School of Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]钟山职业技术学院,江苏南京210049 [2]中国药科大学药学院,江苏南京211198

出　　处：《药学学报》2022年第7期1954-1961,共8页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81872867);江苏省高职院校教师专业带头人高端研修项目(2021GRGDYX003)。

摘　　要：随着我国人口老龄化进程的加快,老年性疾病阿尔茨海默症(Alzheimer’s disease,AD)对社会和家庭的影响日益突出。AD是由多种机制共同影响所致,且发病机制仍未完全阐明,临床的治疗手段大多数采用单一治疗方法,主要以改善症状为主,难以逆转疾病的进程。所以开发出既能改善症状又能逆转疾病进程的药物成为极其迫切的临床需求。越来越多的研究发现中医药在防治AD中具有重要作用。天然产物具有结构新颖、多靶点和活性多样的优势,可作为治疗AD的先导化合物的重要来源。本文对目前临床上正在进行的主要治疗方法和中药中天然成分治疗的研究进展进行概述,结合传统中医药治疗的优势为后续对AD的临床治疗提供参考。With the acceleration of the aging process of our country’s population,the impact of aging-related diseases-Alzheimer’s disease(AD)on society and families has become increasingly prominent.AD is caused by multiple mechanisms,and the pathogenesis has not been fully elucidated.Most of the clinical treatments are single therapy,which mainly focuses on improving symptoms and are difficult to reverse the disease process.Therefore,the development of drugs that can both improve symptoms and reverse the disease process is extremely urgent in clinical.Increasing number of studies has shown that traditional Chinese medicine plays an important role in the prevention and treatment of AD.The natural products have many advantages,such as novel structures,multiple targets and diverse activities,which can be used as an important source of leading compounds for the treatment of AD.The review summarizes the main clinical treatment methods and the research progress of natural ingredients in traditional Chinese medicine,and provides a reference for the follow-up clinical treatment of AD combined with the advantages of traditional Chinese medicine treatment.

关 键 词：阿尔茨海默症 Β-淀粉样蛋白 TAU蛋白 中药 天然产物 

分 类 号：R966[医药卫生—药理学]