中草药对化疗引起的不良反应的预防作用  

Preventive Effect of Chinese Herbal Medicines on Adverse Reactions Caused by Chemotherapy

作　　者：朱雪莹 李忠[1] 郝力争 陈健 陈聪 张雅月[1] ZHU Xueying;LI Zhong;HAO Lizheng;CHEN Jian;CHEN Cong;ZHANG Yayue(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]北京中医药大学东直门医院,北京100700

出　　处：《世界中医药》2022年第13期1939-1943,共5页World Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(81703903)。

摘　　要：癌症严重威胁着全世界人民的健康。化学疗法是人类癌症的主要治疗方法之一。然而,化学疗法的非特异性细胞毒性通常会引起癌症患者难以忍受的严重不良反应。因此,需要探索有效的佐剂策略以预防和减少化学疗法诱导的不良反应。已经使用数千年的中草药与常规化疗药物比较具备很多优势,为探索有效的佐剂提供了丰富的资源,具有预防和减少抗癌化学疗法不良反应的潜力。本文揭示了化学疗法诱发的不良反应,综述了中草药对化疗诱导的骨髓抑制、胃肠道毒性、神经毒性和心脏毒性的预防作用,并讨论了其作用机制。Cancer seriously threatens the health of people all over the world.Chemotherapy is one of the main treatment methods for human cancer.However,the non-specific cytotoxicity of chemotherapy often leads to hefty adverse reactions that are intolerable in cancer patients.Therefore,it is necessary to explore effective adjuvant strategies to prevent and reduce the adverse reactions induced by chemotherapy.Chinese herbal medicines,which have been used for thousands of years,have many advantages compared with conventional chemotherapeutic agents.They can provide abundant resources for exploring effective adjuvants,and have the potential to prevent and reduce the adverse reactions of chemotherapy.This study revealed the adverse reactions induced by chemotherapy,reviewed the preventive effect of Chinese herbal medicines on chemotherapy-induced bone marrow suppression,gastrointestinal toxicity,neurotoxicity,and cardiotoxicity,and discussed the mechanism of action.

关 键 词：中草药 化学疗法 不良反应 骨髓抑制 胃肠道毒性 神经毒性 心脏毒性 癌症 

分 类 号：R273[医药卫生—中西医结合]