基于脑-肠轴学说探讨以脾论治阿尔茨海默病  

Treatment of Alzheimer's Disease from Spleen:Based on the Theory of Brain-gut Axis

作　　者：屈尧 胡镜清[2] 吴珊 王传池 戎菲 QU Yao;HU Jingqing;WU Shan;WANG Chuanchi;RONG Fei(The First Clinical Medical College of Shaanxi University of Chinese Medicine,Xianyang 712046,China;Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]陕西中医药大学第一临床医学院,咸阳712046 [2]中国中医科学院中医基础理论研究所,北京100700

出　　处：《世界中医药》2022年第13期1951-1954,共4页World Chinese Medicine

基　　金：国家重点研发计划中医药现代化研究重点专项(2019YFC1708500);中国中医科学院中医基础理论研究所中央级公益性科研院所基本科研业务费专项资金资助项目(YZ-202051)。

摘　　要：阿尔茨海默病是一种神志异常疾病,病因病机复杂,为本虚标实之病。脑-肠肽作为中枢神经系统与肠神经系统之间传递的一种神经递质,在阿尔茨海默病的发病中起着重要的作用。有研究发现慢性炎症和肠道菌群失衡可能导致认知能力下降。本文基于脑-肠轴学说与阿尔茨海默病的联系,以脾立论,从“痰”“虚”“瘀”3个角度论述与心、与肝、与肾之关系,以祛瘀、化痰、补虚为法来治疗,为中医从脾论治阿尔茨海默病提供理论依据。Alzheimer's disease,a mental disorder with complex pathogenesis,is characterized by deficiency in nature and excess in superficiality.As a neurotransmitter transmitted between central nervous system and the enteric nervous system,brain-gut peptide plays an important role in the pathogenesis of Alzheimer's disease.It has been verified that chronic inflammation and the imbalance of intestinal microflora may lead to cognitive decline.Based on the connection between brain-gut axis theory and Alzheimer's disease,this paper explores the relationship of spleen with the heart,liver,and kidney from three perspectives of“phlegm”,“deficiency”,and“blood stasis”,and discusses the treatment by removing blood stasis,resolving phlegm,and tonifying deficiency,which is expected to lay a theoretical basis for the treatment of Alzheimer's disease from spleen.

关 键 词：脑-肠轴 神经递质 脑-肠肽 肠道微生物 慢性炎症 老年痴呆 综述 退行性疾病 

分 类 号：R277.7[医药卫生—中医学]