血氨检测在早产儿胃肠外营养安全评估的价值及对患儿生化指标的影响  

The Value of Blood Ammonia Detection in the Safety Assessment of Parenteral Nutrition in Premature Infants and Its Influence on the Biochemical Indicators of Children

作　　者：刘会领 李桂芳 刘月娥 谢艳慧 李建英 LIU Huiling;LI Guifang;LIU Yuee;XIE Yanhui;LI Jianying(Department of Neonatology,Cangzhou People's Hospital Yihe Maternity Hospital,Cangzhou,Hebei Province,061000 China)

机构地区：[1]沧州市人民医院颐和妇产医院新生儿科,河北沧州061000

出　　处：《世界复合医学》2022年第5期103-106,共4页World Journal of Complex Medicine

摘　　要：目的探讨血氨检测应用在早产儿胃肠外营养安全的评估价值,并分析其对患儿生化指标的影响。方法选择沧州市人民医院颐和妇产医院妇产科2019年2月—2020年2月出生24 h内胃肠外营养的52例早产儿作为研究组,并选择同期出生的42例无需胃肠外营养的早产儿作为对照组。对照组患儿行早产儿配方奶或母乳喂养,研究组给予等量的胃肠外营养支持。测定两组早产儿喂养前、喂养后2 d、7 d和出院时血氨、前白蛋白及胆红素等生化指标,并比较两组血氨水平变化。结果两组进行肠胃外营养支持和经口喂养第2天后,研究组血氨(188.54±24.16)μmol/L、胆红素水平(31.64±4.20)μmol/L,对照组血氨(176.48±31.65)μmol/L、胆红素水平(26.41±4.00)μmol/L,差异有统计学意义(t=2.095、6.131,P<0.05),喂养7 d后,研究组血氨(229.54±29.85)μmol/L、尿素氮水平(3.94±1.71)mmol/L,对照组血氨(215.24±29.34)μmol/L、尿素氮水平(3.12±1.23)mmol/L,差异有统计学意义(t=2.327、2.609,P<0.05),出院时两组各项生化指标对比,差异无统计学意义(P>0.05)。结论早产儿胃肠外营养支持与母乳喂养早产儿的血氨指标水平有显著差异,临床可以将血氨检测作为早产儿胃肠外营养支持安全评估的指标。Objective To investigate the application value of blood ammonia detection in the evaluation of parenteral nutrition safety in premature infants, and to analyze its influence on biochemical indexes of infants. Methods 52 premature infants who received parenteral nutrition within 24 h of birth in the obstetrics and gynecology department ofCangzhou People’s Hospital Yihe Maternity Hospital from February 2019 to February 2020 were selected as the study group, and 42 premature infants born during the same period without parenteral nutrition were selected as the control group. The children in the control group were given formula milk or breast milk for premature infants, and the study group was given the same amount of parenteral nutrition support. Biochemical indexes such as blood ammonia, prealbumin and bilirubin were measured before feeding, 2 d, 7 d after feeding and discharge in the two groups of premature infants, and the changes of blood ammonia levels in the two groups were compared. Results After parenteral nutrition support and oral feeding for the second day in the two groups, the blood ammonia level in the study group was(188.54±24.16) μmol/L, and the bilirubin level was(31.64±4.20) μmol/L. The blood ammonia level in the control group was(176.48±31.65) μmol/L, and the bilirubin level was(26.41±4.00) μmol/L, the difference was statistically significant(t=2.095, 6.131, P<0.05). After 7 d of feeding, the blood ammonia in the study group was(229.54±29.85)μmol/L, and the urea nitrogen level was(3.94±1.71) mmol/L. The blood ammonia level in the control group was(215.24±29.34) μmol/L, and the blood urea nitrogen level was(3.12±1.23) mmol/L, the difference was statistically significant(t=2.327, 2.609, P<0.05). There was no statistical significance in each biochemical index in the group(P>0.05). Conclusion There are significant differences in blood ammonia index levels between parenteral nutrition support and breastfeeding premature infants in premature infants. Blood ammonia detection can be used as

关 键 词：血氨检测 尿素氮 胆红素 前白蛋白 早产儿 胃肠外营养支持 

分 类 号：R722.6[医药卫生—儿科]