新生儿化脓性脑膜炎的临床分析  

Clinical Analysis of Neonatal Suppurative Meningitis

作　　者：于爱真[1] YU Aizhen(Department of Neonatology,Shenzhen Children's Hospital,Shenzhen,Guangdong Province,518000 China)

机构地区：[1]深圳市儿童医院新生儿科,广东深圳518000

出　　处：《世界复合医学》2022年第6期145-148,共4页World Journal of Complex Medicine

摘　　要：目的对新生儿最主要类型的化脓性脑膜炎的临床表现进行探讨和比较。方法回顾性分析2015年1月-2019年1月深圳市儿童医院收治的102例新生儿化脓性脑膜炎为研究对象,分析明确病原学感染依据病例的主要病原菌。结果102例患儿中47例有明确的病原学证据,B族链球菌(group B streptococcus,GBS)和大肠埃希菌分别占据感染的前2位(38.3%、23.4%)。其中,GBS感染PCT为(53.7±14.9)ng/mL,明显高于大肠埃希菌(6.3±3.0)ng/mL,差异有统计学意义(t=10.353,P<0.05),其他相关指标对比,差异无统计学意义(P>0.05)。结论B族链球菌和大肠埃希菌是引起新生儿化脓性脑膜炎的主要致病菌,二者在实验室感染指标水平上差别不大,但PCT与前者关系更密切,因此PCT可作为早期诊断该病的重要参考指标。Objective To discuss and compare the clinical manifestations of the most important type of neonatal suppurative meningitis.Meth⁃ods A retrospective analysis of 102 cases of neonatal suppurative meningitis admitted to Shenzhen Children's Hospital from January 2015 to January 2019 inflammation as the research object.The main pathogenic bacteria of the cases based on the clear etiological infection were analyzed.Results 47 of the 102 cases had clear etiological evidence.Group B streptococcus(GBS)and Escherichia coli accounted for the top two infections(38.3%,23.4%),respectively.Among them,the PCT of GBS infection was(53.7±14.9)ng/mL,which was significantly higher than that of Escherichia coli(6.3±3.0)ng/mL,and the difference was statistically significant(t=10.353,P<0.05).There was no statistically signifi⁃cant difference in other indicators(P>0.05).Conclusion Group B streptococcus and Escherichia coli are the main pathogens causing neonatal suppurative meningitis.There is little difference between the two in laboratory infection index levels,but PCT is more closely related to the former.Therefore,PCT can be used as an important reference index for early diagnosis of the disease.

关 键 词：新生儿 化脓性脑膜炎 B组链球菌 大肠埃希菌 

分 类 号：R722.1[医药卫生—儿科]