女性支气管哮喘的独特因素:绝经?性激素治疗?  

Unique Factors in Female Bronchial Asthma:Menopause?Hormone Therapy?

作　　者：王小雪 杨慕坤 白文佩(审校) WANG Xiao-xue;YANG Mu-kun;BAI Wen-pei(The Ninth Clinical School of Peking University,Department of Obstetrics and Gynecology,Beijing Shijitan Hospital,Beijing 100038,China;Department of Obstetrics and Gynecology,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China)

机构地区：[1]北京大学第九临床医学院,北京世纪坛医院妇产科,100038 [2]首都医科大学附属北京世纪坛医院妇产科

出　　处：《国际妇产科学杂志》2022年第4期456-460,共5页Journal of International Obstetrics and Gynecology

基　　金：北京市自然科学基金(7202075);北京市医院管理中心临床医学发展专项经费资助(ZYLX202112);首都医科大学附属北京世纪坛医院青年基金(2019-q16)。

摘　　要：支气管哮喘是一种常见的呼吸系统疾病,表现为反复发作的喘息、气急和胸闷等,发病急骤,病情多变,严重时危及生命,给个人和社会带来沉重的负担。女性支气管哮喘的独立影响因素包括过敏原、遗传和环境等,研究表明绝经及性激素治疗也可能是其重要的影响因素。目前国内关于绝经及性激素治疗与支气管哮喘的研究较少,临床医师对此认知不足,容易给围绝经期女性的支气管哮喘的预防和治疗造成困扰。通过总结国内外最新研究,综述绝经、性激素治疗对支气管哮喘发生的影响及作用机制,以期为临床医师提供诊疗指导,为围绝经期女性提供更好的三级预防服务。Bronchial asthma is a common respiratory disease,manifested as recurrent wheezing,shortness of breath,chest tightness and so on.Bronchial asthma attacks are sudden and changeable,and can be life-threatening in severe cases.It brings heavy burden to personal life and social economy.Studies have shown that female bronchial asthma is not only affected by allergens,genetics,environment and other factors,but also menopause and hormone therapy.However,there are few studies on the relationship between menopause,hormone therapy and bronchial asthma in China.The clinician′s insufficient cognition of the relationship between the two has brought great difficulties to the diagnosis and treatment of bronchial asthma in postmenopausal women.This article is to summarize the latest researches at home and abroad,and to review the effect and mechanism of menopause and sex hormone therapy on asthma,with a view to providing guidance for clinicians in diagnosis and treatment,provide better tertiary prevention services for perimenopausal women.

关 键 词：绝经期 围绝经期 雌激素替代疗法 哮喘 孕激素类 

分 类 号：R562.25[医药卫生—呼吸系统]