核因子κB在子宫内膜异位症发病中的作用  

The Role of NF-κB in the Pathogenesis of Endometriosis

作　　者：王嵩 张崴[2] 宋殿荣(审校)[2] WANG Song;ZHANG Wei;SONG Dian-rong(Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Department of Gynecology,Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300250,China)

机构地区：[1]天津中医药大学研究生院,301617 [2]天津中医药大学第二附属医院妇科

出　　处：《国际妇产科学杂志》2022年第4期461-465,共5页Journal of International Obstetrics and Gynecology

基　　金：天津市教育委员会科研计划项目基金(2021ZD021)。

摘　　要：子宫内膜异位症(endometriosis,EMs)是妇科常见及多发病,发病机制尚未完全清楚,已证实其与炎症反应、免疫因素、内分泌及激素等关系密切。核因子κB(nuclear factor-κB,NF-κB)是一种蛋白复合物,在DNA转录、细胞因子合成、细胞凋亡与分化等方面发挥重要作用。异位、在位和正常子宫内膜细胞上NF-κB的表达具有差异性,同时NF-κB在炎症反应、激素合成、黏附因子及血管生成因子等方面发挥重要的作用,而这些方面与EMs的发生、发展关系密切。综述NF-κB在EMs发病中可能的作用,以期为治疗EMs提供新的思路和方法。Endometriosis(EMs)is a common and frequently-occurring disease in gynecology.The pathogenesis of EMs is not fully understood,but it has been proved to be closely related to inflammatory responses,immune factors,endocrine and hormonal factors.Nuclear factor-κB(NF-κB)is a protein complex that plays an important role in DNA transcription,cytokine synthesis,apoptosis and differentiation.NF-κB expression is different in ectopic,in eutopic and normal endometrial cells.NF-κB plays an important role in inflammatory response,hormone synthesis,adhesion factor and angiogenesis factor,which are closely related to the occurrence and development of EMs.The possible role of NF-κB in the pathogenesis of EMs is reviewed in order to provide new ideas and methods for the treatment of EMs.

关 键 词：NF-κB 子宫内膜异位症 细胞因子类 炎症 雌激素类 孕激素类 细胞黏附 血管内皮生长因子类 

分 类 号：R711.71[医药卫生—妇产科学]