乏氧诱导因子-1α联合N末端-脑钠肽前体对老年急性心力衰竭患者院内死亡的预测价值  

Predictive value of hypoxia-inducible factor-1αcombined with N-terminal pro-brain natriuretic peptide on in-hospital death in elderly patients with acute heart failure

作　　者：轩大海 XUAN Dahai(Intensive Care Unit of Shanghai Tianyou Hospital,Shanghai 200333,China)

机构地区：[1]上海天佑医院重症监护室,上海200333

出　　处：《中国民康医学》2022年第14期110-113,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察乏氧诱导因子-1α(HIF-1α)、N末端-脑钠肽前体(NT-proBNP)在老年急性心力衰竭(AHF)患者中的表达情况,并分析二者联合对其院内死亡的预测价值。方法:回顾性分析2020年8月至2021年2月该院收治的120例老年AHF患者的临床资料,根据住院期间患者是否死亡将其分为死亡组、存活组。比较两组血清HIF-1α、NT-proBNP水平,采用Logistic回归分析法分析老年AHF患者院内死亡的危险因素,绘制受试者工作特征曲线(ROC)评价HIF-1α、NT-proBNP单独及联合检测对老年AHF患者院内死亡的预测价值。结果:120例AHF患者中,死亡34例(28.33%),设为死亡组,其余86例设为存活组;死亡组血清HIF-1α、NTproBNP水平均高于存活组,差异有统计学意义(P<0.05);Logistic回归分析结果显示,HIF-1α、NT-proBNP高表达均是老年AHF患者院内死亡的危险因素(OR>1,P<0.05);ROC曲线显示,HIF-1α、NT-proBNP联合检测对老年AHF患者院内死亡的预测价值高于单个指标检测。结论:血清HIF-1α、NT-proBNP高表达是老年AHF患者院内死亡的危险因素,且二者联合检测对其院内死亡具有较高的预测价值。Objective:To observe expressions of hypoxia-inducible factor-1α(HIF-1α)and N-terminal pro-brain natriuretic peptide(NTproBNP)in elderly patients with acute heart failure(AHF),and to analyze predicted value of them on in-hospital death.Methods:The clinical data of 120 elderly patients with AHF admitted to the hospital from August 2020 to February 2021 were retrospectively analyzed,and they were divided into death group and survival group according to whether the patients died during hospitalization.The serum levels of HIF-1αand NT-proBNP were compared between the two groups.Logistic regression analysis was used to analyze the risk factors of in-hospital death in the elderly patients with AHF.Further,the receiver operating characteristic(ROC)curve was drawn to evaluate the predictive values of single HIF-1α,single NT-proBNP alone and their combination on in-hospital mortality in these patients.Results:Among the 120 AHF patients,34 died(28.33%)and set as the death group,and the remaining 86 patients were set as the survival group.The levels of serum HIF-1αand NT-proBNP in the death group were higher than those in the survival group,and the differences were statistically significant(P<0.05).Logistic regression analysis showed that high expressions of HIF-1αand NT-proBNP were the risk factors for in-hospital death in the elderly patients with AHF(OR>1,P<0.05).The ROC curve showed that the combined detection of HIF-1αand NT-proBNP had the highest predictive value for in-hospital death in the elderly patients with AHF.Conclusions:The high expressions of HIF-1αand NT-proBNP are the risk factors for in-hospital death in the elderly patients with AHF.Further,the ROC curve shows that the combined detection of HIF-1αand NT-proBNP has the highest predictive value for in-hospital death in these patients.

关 键 词：乏氧诱导因子-1Α N末端-脑钠肽前体 老年患者 急性心力衰竭 院内死亡 预测价值 

分 类 号：R541.6[医药卫生—心血管疾病]