宫内节育器放置术后生殖道不同感染类型患者炎性因子水平比较  

Comparison of inflammatory factor levels in patients with different types of reproductive tract infection after intrauterine device placement

作　　者：李栋 LI Dong(Luolong District Maternal and Child Health Care and Family Planning Service Center,Luoyang 471000 Henan,China)

机构地区：[1]洛阳市洛龙区妇幼保健计划生育服务中心,河南洛阳471000

出　　处：《中国民康医学》2022年第14期153-155,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:比较宫内节育器放置术后生殖道不同感染类型患者炎性因子水平。方法:回顾性分析2020年1月至2021年1月该中心收治的80例行宫内节育器放置术女性的临床资料。将40例宫内节育器放置术后发生生殖道感染患者设为发生组,40例宫内节育器放置术后未发生生殖道感染者设为未发生组。比较两组及术后生殖道不同感染类型患者宫腔液促炎因子[γ-干扰素(IFN-γ)、肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β]水平和抗炎因子(IL-4、IL-10、IL-13)水平。结果:术后,两组IFN-γ、TNF-α、IL-1β、IL-4、IL-10、IL-13水平均高于术前,且发生组高于未发生组,差异有统计学意义(P<0.05);盆腔炎患者术后IFN-γ、TNF-α、IL-1β、IL-4、IL-10、IL-13水平均高于细菌性阴道病和宫颈炎患者,但细菌性阴道病患者与宫颈炎患者以上指标水平比较,差异均无统计学意义(P>0.05)。结论:宫内节育器放置术后发生生殖道感染患者宫腔液中促炎因子和抗炎因子水平均高于未发生生殖道感染者,且盆腔炎患者促炎因子与抗炎因子水平均高于细菌性阴道病和宫颈炎患者。Objective:To compare inflammatory factor levels in patients with different types of reproductive tract infection after intrauterine device placement.Methods:The clinical data of 80 women with intrauterine device placement who were admitted to the center from January 2020 to January 2021 were retrospectively analyzed.Among these patients,40 patients with reproductive tract infection after intrauterine device placement were set as occurrence group,while 40 patients without reproductive tract infection after intrauterine device placement were set as non-occurrence group.The proinflammatory factor levels in the intrauterine fluid[γ-interferon(IFN-γ),tumor necrosis factorα(TNF-α),interleukin-1β(IL-1β)]and the anti-inflammatory factor levels[interleukin-4(IL-4),IL-10,IL-13]were compared between the two groups and those with different types of reproductive tract infection.Results:After the surgery,the levels of IFN-γ,TNF-α,IL-1β,IL-4,IL-10 and IL-13 in the two groups were higher than those before the surgery;those of the occurrence group were higher than those of the non-occurrence group;and the differences were statistically significant(P<0.05).The postoperative levels of IFN-γ,TNF-α,IL-1β,IL-4,IL-10,and IL-13 in the patients with pelvic inflammatory disease were higher than those in the patients with bacterial vaginosis and cervicitis;however,there were no statistically significant differences between the two groups(P>0.05).Conclusions:The levels of pro-inflammatory factors and anti-inflammatory factors in the uterine fluid of the patients with reproductive tract infection after intrauterine device placement are higher than those of the patients without genital tract infection.Further,the levels of pro-inflammatory factors and anti-inflammatory factors in the patients with pelvic inflammatory disease are higher than those in the patients with bacterial vaginosis and cervicitis.

关 键 词：宫内节育器放置术 生殖道感染 宫腔液 炎性因子 盆腔炎 细菌性阴道病 宫颈炎 

分 类 号：R711[医药卫生—妇产科学]