1型糖尿病与肠道免疫屏障相关性的研究进展  

Research Progress on the Relationship between Type 1 Diabetes Mellitus and Intestinal Immune Barrier

作　　者：刘雨薇(综述) 杨杨[1] 陈鸿志(审校)[2] LIU Yu-wei;YANG Yang;CHEN Hong-zhi(Department of Endocrinology,Tianyou Hospital Affiliated to Wuhan University of Science and technology,Wuhan 432000;Laboratory of Xiangya Second Hospital Affiliated to Central South University,Changsha 410000)

机构地区：[1]武汉科技大学附属天佑医院内分泌科,武汉432000 [2]中南大学附属湘雅二院实验室,长沙410000

出　　处：《微循环学杂志》2022年第3期71-78,共8页Chinese Journal of Microcirculation

基　　金：中南大学糖尿病免疫学教育部重点实验室开放课题(DMkeylab2018-1)。

摘　　要：1型糖尿病(T1DM)由自身免疫所介导,免疫细胞失衡及细胞因子共同参与了T1DM的发生发展。越来越多的研究发现肠道菌群与T1DM存在相关性,而肠道菌群依附于肠道屏障。肠道免疫屏障是防止病原微生物入侵的第一道关口,它通过自身的结构、分泌各种消化酶、利用定植的肠道菌群产生短链脂肪酸以及肠黏膜相关的免疫系统进而调节代谢以及维护免疫平衡。肠道免疫屏障是如何通过代谢以及免疫作用进而影响自身免疫性糖尿病的发生发展尚不十分明确。因此,从肠道免疫屏障(包括肠道机械、化学、生物等方面)着手,探讨T1DM的免疫调控失衡机制,为有效干预自身免疫相关糖尿病提供新思路与途径。Type 1 diabetes mellitus(T1DM)is mediated by autoimmune disease.The imbalance of immune cells and cytokines are involved in the occurrence and development of T1DM.More and more studies have found that intestinal flora was associated with T1DM,and the intestinal flora is attached to the intestinal barrier.Intestinal immune barrier is the first gateway to prevent the invasion of pathogenic microbes.It regulates metabolism and maintains immune balance through its own structure,secreted various digestive enzymes,utilization of short chain fatty acids produced by colonized intestinal flora and immune system related to intestinal mucosa.It is not clear how intestinal immune barrier affects the development of autoimmune diabetes through metabolism and immune function.Therefore,from the intestinal immune barrier(including intestinal mechanism,chemical and biological aspects),we hope to explore the imbalance mechanism of immune regulation of T1DM,and provide new ideas and ways for effective intervention in autoimmune diabetes.

关 键 词：1型糖尿病 免疫细胞 肠道免疫屏障 短链脂肪酸 

分 类 号：R587.1[医药卫生—内分泌]