高血压靶器官微血管病变及其治疗进展  

Microvascular Disorder in Target Organs of Hypertension and its Therapeutic Progress

作　　者：裴德根 李永光(综述) 陈文佳(审校)[1] PEI De-gen;LI Yong-guang;CHEN Wen-jia(Department of Cardiology,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院,哈尔滨150001

出　　处：《微循环学杂志》2022年第3期79-82,共4页Chinese Journal of Microcirculation

摘　　要：微循环是维持机体正常功能的重要生理基础。微血管损伤和功能障碍可引起高血压发生、发展,高血压通过炎症及氧化应激等所致微血管重构和稀疏,可进一步增加外周阻力提高血压,引起靶器官如心、脑、肾、眼等的损伤。临床通过控制血压、改善内皮功能及消炎和抗氧化应激等策略可有效改善高血压靶器官微血管病变。Microcirculation is an important physiological basis for maintaining the normal function of the body.Microvascular injury and dysfunction can cause the occurrence and development of hypertension,hypertension through inflammation and oxidative stress can cause microvascular remodeling and rarefaction,further increase peripheral resistance to increase blood pressure,causing target organs such as heart,brain,kidney,eyes and other injuries.Clinical strategies such as controlling blood pressure,improving endothelial function,anti-inflammatory and anti-oxidative stress can effectively improve hypertension target organ microangiopathy.

关 键 词：高血压 微循环 心脏 脑 肾 视网膜 

分 类 号：R331.3[医药卫生—人体生理学] R541.4[医药卫生—基础医学]