上海市某区老年人肺炎链球菌IgG抗体水平分析  

Seroprevalence of anti-Streptococcus pneumoniae antibody in the elderly attending physical examination in a district of Shanghai

作　　者：卑伟慧[1] 沈天寒 蔡明毅[1] 沈琦[1] 胡宏[1] 徐翠伟[1] 沈冰[1] BEI Weihui;SHEN Tianhan;CAI Mingyi;SHEN Qi;HU Hong;XU Cuiwei;SHEN Bing(Jing’an District Center for Disease Control and Prevention,Shanghai 200072,China;Jing’an Temple Community Health Care Center,Shanghai 200041,China)

机构地区：[1]上海市静安区疾病预防控制中心,上海200072 [2]上海市静安寺社区卫生服务中心,上海200040

出　　处：《上海预防医学》2022年第6期583-586,595,共5页Shanghai Journal of Preventive Medicine

基　　金：上海市静安区卫生计生系统“十百千”青年人才课题(JWRC2014Q25)。

摘　　要：【目的】了解老年人肺炎链球菌血清抗体水平,分析肺炎链球菌免疫球蛋白G(IgG)抗体水平的相关因素。【方法】随机选取上海市某区2个街道,对体检的65岁以上的老年人开展问卷调查,收集体检信息,并检测血清肺炎链球菌抗体。采用χ^(2)检验和多因素logistic回归分析方法分析肺炎链球菌IgG抗体水平的相关因素。【结果】研究对象共635名,年龄为(73.2±7.4)岁,49名(7.72%)检出肺炎链球菌IgG抗体阳性;男性肺炎链球菌IgG抗体阳性率为6.49%,女性肺炎链球菌IgG抗体为8.86%;吸烟、不吸烟的肺炎链球菌IgG抗体阳性率分别为5.48%、8.01%;最近1年是否患肺炎的肺炎链球菌IgG抗体阳性率分别为7.89%、7.71%;最近1年是否感冒的肺炎链球菌IgG抗体阳性率分别为10.38%、5.87%;是否肥胖的肺炎链球菌IgG抗体阳性率分别为15.62%、6.83%。多因素logistic回归分析显示,肺炎链球菌IgG抗体水平与感冒(OR:2.24;95%CI:1.21~4.14)和肥胖(OR:2.81;95%CI:1.26~6.26)有关联,差异均有统计学意义(均P<0.05)。【结论】本区老年人肺炎链球菌IgG抗体阳性率整体处于较低水平,应扩大宣传,推荐易感冒和肥胖的老年人接种肺炎疫苗。[Objective] To determine the seroprevalence of anti-Streptococcus pneumoniae immunoglobulin G(IgG) antibody and its risk factors in the elderly attending physical examination.[Methods]Two communities were randomly selected,in which the elderly aged over 60years attending physical examination in the community health care centers were included in the study. A questionnaire survey was conducted,companied by examination for serum anti-Streptococcus pneumoniae IgG antibody. In addition,data of physical examination was collected. Chisquare test and multivariate logistic regression were utilized to determine the risk factors associated with seroprevalence of anti-Streptococcus pneumoniae antibody.[Results]A total of 635 participants were included. The average age was(73.2±7.4)years old. Forty-nine(7.72%)participants tested positive for anti-Streptococcus pneumoniae IgG antibody. The seroprevalence differed by gender(6.49% in male and 8.86% in female),smoking(5.48% in smokers and 8.01% in non-smokers),history of pneumonia(7.89% in those suffered from pneumonia in the past year and 7.71% in those didn’t have pneumonia),history of common cold(10.38% in those had common cold in the past year and 5.87% in those didn’t have cold),obesity(15.62% in those with obesity and 6.83% in those without obesity). Further multivariate logistic regression showed the seroprevalence of anti-Streptococcus pneumoniae IgG significantly increased in the elderly with history of common cold(OR:2.24;95%CI:1.21-4.14)and obesity(OR:2.81;95%CI:1.26-6.26).[Conclusion]Seroprevalence of anti-Streptococcus pneumoniae IgG antibody is low in the elderly attending physical examination. It warrants improving the vaccination of pneumococcal polysaccharide vaccine for the elderly with obesity and susceptibility to common cold.

关 键 词：老年人 肺炎链球菌 抗体 

分 类 号：R186[医药卫生—流行病学]