Visible-light-promoted Radical Cyclization/Arylation Cascade for the Construction of α,α-Difluoro-γ-Lactam-Fused Quinoxalin-2(1H)-Ones  

作　　者：Yun-Chao Zhang Yang Chen Jing Sun Jing-Yun Wang Ming-Dong Zhou 

机构地区：[1]School of Petrochemical Engineering,Liaoning Petrochemical University,Fushun,Liaoning 113001,China

出　　处：《Chinese Journal of Chemistry》2022年第6期713-718,共6页中国化学（英文版）

基　　金：We thank the National Natural Science Foundation of China(No.21101085);the Natural Science Foundation of Liaoning Province(No.2015020196);the Liaoning Revitalization Talents Program(No.XLYC1902085);the PetroChina Innovation Foundation(No.2018D-5007-0507);the Research Project Fund of Liaoning Provincial Department of Education(No.L2019037)for the financial supports.

摘　　要：A visible-light-induced tandem radical intramolecular cyclization/arylatiion of quinoxalin-2(1H)-ones with bromodifluoroacetamides is described.This protocol allows efficient access to a variety of valuableα,α-difluoro-y-lactam-fused quinoxalin-2(1H)-ones in moder-ate to good yields under metal-free,mild and redox neutral reaction conditions.This strategy is tolerant of various functional groups and a broad range of substrates.The mechanism experiments suggested an involvement of 5-exo-trig cyclization and a radical pro-cess in this transformation.

关 键 词：Photocatalysis Cyclization Radicals Fluoro-γ-lactams Quinoxalin-2(1H)-ones 

分 类 号：O62[理学—有机化学]