硅烷化聚琥珀酰亚胺负载阿维菌素的制备与性能  

Preparation and properties of silanylated polysuccinimide-loaded avermectin

作　　者：苏少纯 林成威 周新华[1,3] 周红军 SU Shaochun;LIN Chengwei;ZHOU Xinhua;ZHOU Hongjun(Key Laboratory of Agricultural Green Fine Chemicals of Guangdong Higher Education Institution,School of Chemistry and Chemical Engineering,Zhongkai University of Agriculture and Engineering,Guangzhou 510225,Guangdong,China;Guangdong Provincial Key Laboratory of Sustainable Control of Fruit and Vegetable Diseases and Pests,Institute of Plant Health Innovation,Guangzhou 510225,Guangdong,China;Maoming Branch,Guangdong Laboratory for Lingnan Modern Agriculture,Maoming 525000,Guangdong,China)

机构地区：[1]仲恺农业工程学院化学化工学院,广东省普通高校农用绿色精细化学品重点实验室,广东广州510225 [2]植物健康创新研究院,广东省普通高校果蔬病虫害可持续防治重点实验室,广东广州510225 [3]岭南现代农业科学与技术广东省实验室茂名分中心,广东茂名525000

出　　处：《化工进展》2022年第8期4481-4490,共10页Chemical Industry and Engineering Progress

基　　金：广东省农业产业技术体系共性关键技术(农业纳米)创新团队项目(2019KJ140);广州市科技计划(201903010011);广东省国际科技合作项目(2021A050530073);植物健康创新研究院科研项目(KA21031H105)。

摘　　要：为了减少农药的流失和降解,采用纳米材料与技术开发新型纳米剂型具有巨大潜力。本文以3-氨丙基三乙氧基硅烷(APTES)和丁二胺(DBA)为改性单体,采用胺解开环反应制备了硅烷化聚琥珀酰亚胺(PDSi),并通过自组装方式负载阿维菌素(AVM)得到AVM@PDSi纳米体系。结果表明,相较于原药,AVM@PDSi对叶面的黏附性明显提升,叶面滞留量提高了56.50%。PDSi材料具有良好的抗氧化活性,PDSi对1,1-二苯基-2-苦基肼(DPPH)自由基的清除率最高可达41.88%。AVM@PDSi具有良好的抗紫外性能,在相同的紫外强度照射下(E_(max)=365nm),AVM@PDSi半衰期比原药AVM延长了近一半。AVM@PDSi具有良好的缓释性能和pH响应释放性能,在pH=9时释放最快;在pH=7时,AVM@PDSi-3在72h后累积释放量为67%。研究表明,AVM@PDSi具有良好的储存稳定性,并且保留了AVM的杀虫活性。In order to reduce the loss and degradation of pesticides,the nanomaterial and nanotechnologies have great potential to develop new nanoformulation.Silanylated polysuccinimide(PDSi)was prepared by the amine bond ring-opening reaction with 3-aminopropyl triethoxysilane and diaminobutane as functional monomers,which encapsulated avermectim(AVM)via self-assembly to form AVM@PDSi nanoparticles system.Compared with bare AVM,the leaves adhesion of AVM@PDSi is significantly improved with its leaf retention increased by 56.50%.Moreover,PDSi has good antioxidant activity with the maximum scavenging rate of 1,1-diphenyl-2-picrylhydrazide(DPPH)free radical being up to 41.88%.Under the same UV irradiation(E_(max)=365nm),the half-life of AVM(AVM@PDSi)is nearly half longer than bare AVM.Also,AVM@PDSi can intelligently control pesticide release by adjusting monomer ratio and pH,with the releasing rate for AVM@PDSi-3 being 67%after 72h and the fastest releasing at pH 9.More importantly,AVM@PDSi shows the good storage stability and retains the toxicity for insecticidal effect.

关 键 词：聚琥珀酰亚胺 硅烷化 纳米材料 载体 稳定性 

分 类 号：TQ028.8[化学工程]