银催化2-烯基苯胺与苯并异噁唑的[5+1]环化反应  

Silver-catalyzed[5+1]Cyclization of 2-Vinylanilines with Benzisoxazoles

作　　者：葛怡聪 聂万丽[1] 孙国峰 陈稼轩[1] 田冲[1] GE Yicong;NIE Wanli;SUN Guofeng;CHEN Jiaxuan;TIAN Chong(Sichuan Province Key Laboratory of Natural Products and Small Molecule Synthesis,School of New Energy Materials and Chemistry,Leshan Normal University,Leshan 614000,China)

机构地区：[1]乐山师范学院新能源材料与化学学院,天然产物化学与小分子催化四川省高校重点实验室,乐山614000

出　　处：《高等学校化学学报》2022年第8期111-118,共8页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21542011);四川省科技厅计划项目(批准号:2020YJ0358);乐山师范学院科研项目(批准号:RC2021006,Z1414)资助。

摘　　要：利用廉价易得的2-胺基苯乙烯与苯并异噁唑在银催化下发生[5+1]串联环化反应,以中等至优异的收率一步得到含有N,N-双齿螯合片段的2-喹啉基苯胺衍生物.该方法具有宽泛的底物普适性、较高的原子经济性和温和的反应条件等优势,为合成这类具有广泛用途的N,N-双齿螯合分子提供了新的研究思路.A novel and facile silver-catalyzed[5+1]annulation reaction between 2-vinylanilines with benzisoxazoles was developed,resulting in the rapid formation of structurally diversified 2-quinolinylaniline derivatives containing N,N-bidentate chelating skeleton in moderate to excellent yields.This protocol features broad substrate scope,high atom-economy,mild reaction conditions and so forth,which provides a new idea for the synthesis of N,N-bidentate chelating molecules widely used.

关 键 词：2-烯基苯胺 苯并异噁唑 [5+1]环化 2-喹啉基苯胺 N N-双齿螯合分子 

分 类 号：O626[理学—有机化学]