增液麻仁汤穴位敷贴联合莫沙必利治疗颅脑外伤后便秘临床研究  

Clinical Study on Point Application with Zengye Maren Tang Combined with Mosapride for Constipation After Craniocerebral Trauma

作　　者：苏微微 徐志伟 李秀萍 SU Weiwei;XU Zhiwei;LI Xiuping

机构地区：[1]桐乡市第一人民医院,浙江桐乡314500

出　　处：《新中医》2022年第14期45-48,共4页New Chinese Medicine

基　　金：桐乡市引导性科技计划项目(201902293)。

摘　　要：目的:观察增液麻仁汤穴位敷贴联合莫沙必利治疗颅脑外伤后便秘的临床疗效。方法:选取86例颅脑外伤后便秘患者,以随机数字表法分为对照组和观察组各43例。对照组给予枸橼酸莫沙必利片治疗,观察组在对照组基础上加用增液麻仁汤穴位敷贴治疗,2组均治疗2周。比较2组临床疗效、不良反应发生率,比较2组治疗前后便秘程度、血清炎性因子水平。结果:观察组总有效率95.35%,高于对照组81.40%(P<0.05)。治疗后,2组Cleveland便秘评分量表(CCS)、便秘患者症状自评量表(PAC-SYM)评分均较治疗前降低(P<0.05),观察组CCS、 PAC-SYM评分均低于对照组(P<0.05)。治疗后,2组血清C-反应蛋白(CRP)、白细胞介素-1β (IL-1β)、肿瘤坏死因子-α (TNF-α)水平均较治疗前降低(P<0.05),观察组血清CRP、IL-1β、TNF-α水平均低于对照组(P<0.05)。观察组不良反应发生率9.30%,与对照组4.65%比较,差异无统计学意义(P>0.05)。结论:增液麻仁汤穴位敷贴联合莫沙必利治疗颅脑外伤后便秘,可显著改善便秘症状,降低血清炎性因子水平,临床疗效和安全性均较好。Objective: To observe the clinical effect of point application with Zengye Maren tang combined with mosapride for constipation after craniocerebral trauma. Methods:A total of 86 patients with constipation after craniocerebral trauma were selected and divided into the control group and the observation group according to the random number table method,with 43 cases in each group. The control group was treated with mosapride citrate tablets, and the observation group was additionally treated with point application with Zengye Maren tang based on the treatment of the control group. Both groups were treated for two weeks. The degree of constipation and the levels of inflammatory factors in serum before and after treatment,as well as the clinical effects and the incidence of adverse reactions in the two groups were compared. Results: The total effective rate was 95.35% in the observation group, higher than that of81.40% in the control group(P<0.05). After treatment, the scores of Cleveland Constipation Score(CCS)and Patient Assessment of Constipation Symptoms(PAC-SYM) in the two groups were decreased when compared with those before treatment(P<0.05),and the scores of CCS and PAC-SYM in the observation group were lower than those in the control group(P<0.05). After treatment,the levels of C-reactive protein (CRP), interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α) in serum in the two groups were decreased when compared with those before treatment(P<0.05), and the levels of CRP, IL-1β and TNF-α in serum in the observation group were lower than those in the control group(P<0.05). The incidence of adverse reactions was 9.30% in the observation group and 4.65% in the control group,there being no significance in the difference(P>0.05). Conclusion: Point application with Zengye Maren tang combined with mosapride for constipation after craniocerebral trauma can significantly improve the symptom of constipation and decrease levels of inflammatory factors in serum,with good clinical effect and safety.

关 键 词：颅脑外伤后便秘 增液麻仁汤 穴位敷贴 莫沙必利 Cleveland便秘评分量表 便秘患者症状自评量表 炎性因子 

分 类 号：R256.35[医药卫生—中医内科学]