复方血栓通胶囊联合激光光凝术治疗视网膜中央静脉阻塞临床研究  

Clinical Study on Compound Xueshuantong Capsules Combined with Laser Photocoagulation for Central Retinal Vein Occlusion

作　　者：冯水锋 赵炳坤 FENG Shuifeng;ZHAO Bingkun

机构地区：[1]绍兴市越城区人民医院眼科,浙江绍兴312000

出　　处：《新中医》2022年第14期120-123,共4页New Chinese Medicine

摘　　要：目的:观察复方血栓通胶囊联合激光光凝术治疗视网膜中央静脉阻塞(CRVO)的临床疗效。方法:选取102例CRVO患者,按随机数字表法分为对照组和治疗组各51例。对照组采取激光光凝术治疗,治疗组在对照组基础上给予复方血栓通胶囊治疗。比较2组治疗前后视网膜血流动力学指标及可溶性细胞间黏附分子-1 (ICAM-1)、单核细胞趋化蛋白-1 (MCP-1)、肿瘤坏死因子-α (TNF-α)水平,比较2组临床疗效及不良发应发生率。结果:治疗组总有效率96.08%,高于对照组82.35%(P<0.05)。治疗后,2组搏动指数(PI)、阻力指数(RI)均较治疗前降低(P<0.05),舒张末期血流速度(EDV)、收缩期峰值血流速度(PSV)均较治疗前增大(P<0.05);治疗组PI、RI均低于对照组(P<0.05),EDV、PSV均大于对照组(P<0.05)。治疗后,2组ICAM-1、MCP-1、TNF-α水平均较治疗前降低(P<0.05),治疗组ICAM-1、MCP-1、TNF-α水平均低于对照组(P<0.05)。对照组不良反应发生率9.80%,治疗组不良反应发生率7.84%,2组比较,差异无统计学意义(P>0.05)。结论:复方血栓通胶囊联合激光光凝术治疗CRVO可提高临床疗效,改善患者的眼部血液循环,降低ICAM-1、MCP-1、TNF-α水平,且安全性较好。Objective: To observe the clinical effect of compound Xueshuantong capsules combined with laser photocoagulation for central retinal vein occlusion(CRVO). Methods:A total of 102 cases of CRVO patients were selected and divided into the control group and the treatment group according to the random number table method, with 51 cases in each group. The control group was treated with laser photocoagulation, and the treatment group was additionally treated with compound Xueshuantong capsules based on the treatment of the control group. Retinal hemodynamic indexes and the levels of soluble intercellular adhesion molecule-1(ICAM-1), monocyte chemoattractant protein-1(MCP-1) and tumor necrosis factor-α(TNF-α) before and after treatment in the two groups were compared;the clinical effects and incidence of adverse reactions in the two groups were compared. Results:The total effective rate was 96.08% in the treatment group,higher than that of 82.35% in the control group(P<0.05). After treatment,the pulsatility indexes(PI) and resistance indexes(RI) in the two groups were decreased when compared with those before treatment(P<0.05), and the end diastolic velocity(EDV) and peak systolic blood flow velocity(PSV) were increased when compared with those before treatment(P<0.05);PI and RI in the treatment group were lower than those in the control group(P<0.05);EDV and PSV were higher than those in the control group(P<0.05). After treatment,the levels of ICAM-1,MCP-1 and TNF-α in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of ICAM-1,MCP-1 and TNF-α in the treatment group were lower than those in the control group(P<0.05). The incidence of adverse reactions was 9.80% in the control group and 7.84% in the treatment group,there being no significant difference between the two groups(P>0.05). Conclusion:The therapy of compound Xueshuantong capsules combined with laser photocoagulation for CRVO can enhance the clinical effect,improve the ocular blood circulation,and reduce the level

关 键 词：视网膜中央静脉阻塞 复方血栓通胶囊 激光光凝术 血流动力学 可溶性细胞间黏附分子-1 单核细胞趋化蛋白-1 肿瘤坏死因子-α 

分 类 号：R276.7[医药卫生—中医五官科学]