硅球担载聚合物整体柱的制备及评价  

Preparation and Evaluation of the Silica Particles Supported Polymer Monolithic Column

作　　者：安然 AN Ran(Shenyang Institute of Science and Technology,Shenyang Liaoning 110167,China)

机构地区：[1]沈阳科技学院,辽宁沈阳110167

出　　处：《辽宁化工》2022年第8期1054-1056,1061,共4页Liaoning Chemical Industry

摘　　要：制备了一种硅球担载聚合物整体柱(担载柱)。这种担载柱是在内径为250μm的石英毛细管中,在致孔剂水、甲醇和环己醇的存在下,以直径为5μm的裸硅球为载体,通过原位聚合甲基丙烯酸,2-二甲基乙基胺甲基丙烯酸酯和乙二醇二甲基丙烯酸酯制成的。在担载柱中,有机聚合物以纳米级小颗粒的形式薄薄的包覆在硅球表面,使硅球联结在一起的同时,留有一定的空隙供流动相通过。通过观察扫描电镜和压力-流速关系曲线对担载柱的制备条件进行优化,并在相同的实验条件下,将担载柱与有机聚合物整体柱(有机柱)的固定相表面形态、机械稳定性、渗透性、柱效等方面进行对比。实验结果表明,除了渗透性,担载柱的各项性能均优于有机柱。A silica particles supported polymeric monolithic column, shortened as the supported column(S-column), was prepared by in-situ polymerization of methacrylic acid, ethylene dimethacrylate and 2-(dimethyl amino) ethyl methacrylate in the presence of a ternary porogenic solvent containing water, methanol and cyclohexanol in a 250 μm i.d. fused silica capillary pre-packed with 5 μm bare silica particles. In the support column, the organic polymer was thinly coated on the surface of the silicon spheres in the form of nano-sized particles, so that while the silicon spheres were connected together, a certain gap was left for the mobile phase to pass through. The preparation conditions of the supported column were optimized by observing the scanning electron microscope and the pressure-flow rate curve, the S-column was evaluated by comparison with its conventional organic counterpart in terms of morphology,mechanical stability, permeability, swelling-shrinking behavior, capacity and efficiency. The results demonstrated that the S-column was superior to its counterpart in all the terms with the exception of permeability.

关 键 词：微柱高效液相色谱 整体柱 硅球 

分 类 号：O657[理学—分析化学]