铁催化的N-烷基化反应研究进展  

Research Progress of Iron-catalyzed N-alkylation Reactions

作　　者：步亚楠 BU Ya-nan(College of Chemistry and Material Engineering,Wenzhou University,Wenzhou Zhejiang 325035,China)

机构地区：[1]温州大学化学与材料工程学院,浙江温州325035

出　　处：《辽宁化工》2022年第8期1118-1120,1140,共4页Liaoning Chemical Industry

摘　　要：含氮化合物在药物和生物活性分子中广泛存在,因此N-烷基化反应在有机合成领域中十分重要。主要讨论了以铁为催化剂促进的N-烷基化反应。催化体系由一系列的铁催化剂与配体、添加剂共同组成,反应通常具有优异的收率。铁催化N-烷基化反应为有机合成开辟了新途径,具有重要的研究意义。Nitrogenous compounds widely exist in bioactive molecules and drugs, therefore N-alkylation is very important in organic synthesis. In this paper, the N-alkylation reaction catalyzed by iron was mainly discussed. The catalytic system consists of a series of iron catalysts together with ligands and additives, and the reaction usually has excellent yields. Iron-catalyzed N-alkylation opens up new avenues for organic synthesis with important research significance.

关 键 词：铁催化 N-烷基化 胺 

分 类 号：O621.255.8[理学—有机化学]