抗癌青黄汤联合羟基脲片治疗慢性髓系白血病60例临床观察  

Clinical effect of Kang’ai Qinghuang decoction combined with hydroxycarbamide tablets in treatment of chronic myeloid leukemia:An analysis of 60 cases

作　　者：毕思源 钟新林 BI Siyuan;ZHONG Xinlin(Hunan University of Chinese Medicine,Changsha 410208,Hunan,China;Hengyang Hospital Affiliated to Hunan University of Chinese Medicine,Hengyang 421001,Hunan,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南中医药大学附属衡阳医院,湖南衡阳421001

出　　处：《湖南中医杂志》2022年第7期16-19,共4页Hunan Journal of Traditional Chinese Medicine

摘　　要：目的:观察抗癌青黄汤联合羟基脲片治疗慢性髓系白血病(CML)慢性期毒热炽盛证的临床疗效。方法:将60例CML慢性期毒热炽盛证患者随机分为治疗组和对照组,每组各30例。对照组给予羟基脲片治疗,治疗组在对照组基础上加用抗癌青黄汤治疗。2组均以4周为1个疗程,治疗2个疗程后观察2组的综合疗效、白细胞计数、骨髓中不成熟粒细胞水平、中医证候积分以及不良反应。结果:总有效率治疗组为86.67%(26/30),高于对照组的70.00%(21/30),2组比较,差异有统计学意义(P<0.05);2组白细胞计数、骨髓中不成熟粒细胞水平、中医证候积分治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.05或P<0.01);不良反应发生率治疗组为13.33%(4/30),低于对照组的20.00%(6/30),组间比较,差异无统计学意义(P>0.05)。结论:抗癌青黄汤联合羟基脲片治疗CML慢性期毒热炽盛证疗效较佳,能改善患者临床症状和造血功能,值得临床推广应用。Objective:To investigate the clinical effect of Kang’ai Qinghuang decoction combined with hydroxycarbamide tablets in the treatment of the chronic stage of chronic myeloid leukemia(CML)with excessive toxic heat syndrome.Methods:A total of 60 patients in the chronic stage of CML with excessive toxic heat syndrome were randomly divided into treatment group and control group,with 30 patients in each group.The patients in the control group were given hydroxycarbamide tablets,and those in the treatment group were given Kang’ai Qinghuang decoction in addition to the treatment in the control group.Each course of treatment was 4 weeks,and after 2 courses of treatment,the two groups were observed in terms of overall response,leukocyte count,percentage of immature neutrophils,traditional Chinese medicine(TCM)syndrome score,and adverse reactions.Results:The treatment group had a significantly higher overall response rate than the control group[86.67%(26/30)vs 70.00%(21/30),P<0.05].After treatment,both groups had significant changes in leukocyte count,percentage of immature neutrophils,and TCM syndrome score,and there were significant differences in these indices between the two groups after treatment(P<0.05 or P<0.01).The treatment group had a lower incidence rate of adverse reactions than the control group[13.33%(4/30)vs 20.00%(6/30),P>0.05].Conclusion:Kang’ai Qinghuang decoction combined with hydroxycarbamide tablets has a good clinical effect in the treatment of patients in the chronic stage of CML with excessive toxic heat syndrome and can improve clinical symptoms and hematopoietic function,and thus it holds promise for clinical application.

关 键 词：慢性髓系白血病 慢性期 毒热炽盛证 中西医结合疗法 抗癌青黄汤 羟基脲 

分 类 号：R273.37[医药卫生—中西医结合]