部分遗传性皮肤病的治疗进展  

Treatment of some genodermatoses

作　　者：晋亮 刘玲[2] Jin Liang;Liu Ling(Department of Dermatology,Air Force Medical Center,PLA,Beijing 100142,China;Department of Dermatology,Xijing Hospital,The Fourth Military Medical University,Xi′an 710032,China)

机构地区：[1]解放军空军特色医学中心,北京100142 [2]第四军医大学西京皮肤医院,西安710032

出　　处：《中华皮肤科杂志》2022年第8期735-739,共5页Chinese Journal of Dermatology

基　　金：空军军医大学"人才工程雏鹰计划"项目(KT2021HQ021)。

摘　　要：遗传性皮肤病是皮肤病中相对独立的体系,发病较早、临床表现复杂、累及系统多,目前治疗手段有限且疗效欠佳,患者生活质量受到较大影响。本文梳理总结部分遗传性皮肤病的前瞻性治疗方法和研究进展,包括传统药物的创新应用、生物制剂和小分子靶向药物、干细胞治疗和基因编辑,旨在为临床医生提供更多参考。Genodermatoses are a relatively independent type of skin diseases,with early onset,complex clinical manifestations and multiple system involvement.Current treatments of genodermatoses are still limited with poor therapeutic effect,and the quality of life of patients is greatly affected.This review summarizes prospective treatment methods of some hereditary skin diseases and related research progress,including innovative application of traditional medicines,biologics and small-molecule targeted drugs,stem cell therapy and gene editing,aiming to provide more reference for clinicians.

关 键 词：皮肤疾病 遗传性 治疗 生物制剂 干细胞 小分子靶向药 基因编辑 

分 类 号：R758.5[医药卫生—皮肤病学与性病学]