非ST段抬高型心肌梗死并发肺炎临床危险因素分析  

Analysis of clinical risk factors of pneumonia in patients with non-ST segment elevation myocardial infarction

作　　者：静亮 彭希 李大勇[1] 祝伟[1] JING Li-ang;PEN Xi;LI Da-yong(Department of Emergency-Critical Medicine,Tongji Hospital,Tongji Medical,Huazhong University of Science and Technology,Wuhan 430000,China;Department of Internal Neurolo-gy,Tongji Hospital,Tongji Medical,Huazhong University of Science and Technology,Wuhan 430000,China)

机构地区：[1]华中科技大学同济医学院附属同济医院急诊-重症医学科,湖北武汉430000 [2]华中科技大学同济医学院附属同济医院神经内科,湖北武汉430000

出　　处：《中国实验诊断学》2022年第7期962-966,共5页Chinese Journal of Laboratory Diagnosis

摘　　要：目的 探讨非ST段抬高型心肌梗死并发肺炎临床危险因素。方法 回顾性分析2020年1月-2021年1月同济医院收治的117例非ST段抬高型急性心肌梗死患者的临床资料。根据是否并发肺炎,67例NSTEMI患者为对照组,NSTEMI合并肺炎者50例为观察组。采用Lasso回归筛选影响因素,Logistic多因素回归分析危险因素。采用受试者工作特征曲线分析氨基末端B型利钠肽前体、C反应蛋白对非ST段抬高型心肌梗死并发肺炎的诊断价值。结果①氨基末端B型利钠肽前体、C反应蛋白是非ST段抬高型心肌梗死并发肺炎的独立危险因素(P<0.05)。②NTproBNP对NSTEMI并发肺炎ROC曲线下面积最大(AUC=0.782)。NT-proBNP临界值869.80pg/mL,约登指数0.45,敏感度66.00%,特异度79.10%;CRP临界值15.11mg/L,约登指数0.525,敏感度60.00%,特异度92.50%。结论氨基末端B型利钠肽前体、C反应蛋白是非ST段抬高型心肌梗死并发肺炎的早期临床危险因素。Objective To investigate the clinical risk factors of non-ST segment elevation myocardial infarction(NSTEMI)complicated with pneumonia.Methods The clinical data of 117 patients with NSTEMI in Tongji hospital from January 2020 to January 2021 were analyzed retrospectively.According to the results of pneumonia,67 patients with NSTEMI were in the control group and 50 patients with NSTEMI were in the observation group.Lasso regression was used to screen the influencing factors,and logistic regression was used to analyze the risk factors.The diagnostic value of amino-terminal pro-B-type natriuretic peptide(NT-proBNP)and C-reactive protein(CRP)in patients with NSTEMI complicated with pneumonia was analyzed by working characteristic curve.Results (1)NT-proBNP and CRP were independent risk factors of pneumonia in NSTEMI(P<0.05).(2)NT-proBNP had the largest area under ROC curve of NSTEMI complicated with pneumonia(AUC=0.782).NT-proBNP’s critical value is 869.80pg/ml,Jordan index is 0.45 with 66.00% sensitivity,79.10 specificity.CRP’s critical value is 15.11mg/L,Jordan index is 0.525 with 60.00% sensitivity,92.50% specificity.Conclusion NT-proBNP and CRP are the early clinical risk factors of patients with NSTEMI and pneumonia.

关 键 词：肺炎 非ST段抬高型心肌梗死 危险因素 

分 类 号：R542.22[医药卫生—心血管疾病]