正交试验优选头痛方水提工艺  

Optimization of Water Extraction Process of Toutong Recipe by the Orthogonal Test

作　　者：郑粤文 陈秋谷 张尚斌[3,4] 张志强[1,2] 周国莉 吴红彦 陈剑平 ZHENG Yuewen;CHEN Qiugu;ZHANG Shangbin;ZHANG Zhiqiang;ZHOU Guoli;WU Hongyan;CHEN Jianping(Shenzhen Luohu District Chinese Medicine Hospital,Shenzhen,Guangdong,China 518001;Shenzhen Hospital of Shanghai University of Tradi-tional Chinese Medicine,Shenzhen,Guangdong,China 518001;The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen,Guangdong,China 518033;Shenzhen Traditional Chinese Medicine Hospital·Shenzhen Key Laboratory of Hospital Chinese Medicine Preparation,Shenzhen,Guangdong,China 518033)

机构地区：[1]广东省深圳市罗湖区中医院,广东深圳518001 [2]上海中医药大学深圳医院,广东深圳518001 [3]广州中医药大学第四临床医学院,广东深圳518033 [4]广东省深圳市中医院·深圳市医院中药制剂研究重点实验室,广东深圳518033

出　　处：《中国药业》2022年第16期53-56,共4页China Pharmaceuticals

基　　金：广东省深圳市医疗卫生“三名工程”项目[SZZYSM202111002]。

摘　　要：目的优选头痛方的水提工艺。方法以共有峰主成分综合评分、4个主成分总含量、总固形物质量加权系数分别为0.3,0.4,0.3的总评分为评价指标,加水量、煎煮次数、煎煮时间为考察因素,采用L_(9)(3^(4))正交试验法优选头痛方水提工艺。结果优选的最佳水提工艺为加8倍量水,煎煮3次,每次1.0 h,验证试验表明该工艺可行。结论该水提工艺客观全面,能兼顾大部分成分种类与含量的变化情况,实现中药及其产品整个生产过程的质量控制、质量传递与质量追溯。Objective To optimize the water extraction process of Toutong Recipe.Methods The water extraction process of Toutong Recipe was optimized by the L_(9)(3^(4))orthogonal test with the comprehensive score of common peak components,the total content of four principal components,the total score of total solid with weighting coefficient of 0.3,0.4,0.3 as the evaluation indexes,and with the amount of water addition,the decocting times,and the decocting time as the evaluation factors.Results The optimal water extraction process was as follows:adding eight times the amount of water,decocting three times,each time for 1.0 h.The verification test showed that the process was feasible.Conclusion The water extraction process is more objective and comprehensive,which can take into account the changes of most component types and contents,and realize the quality control,quality transmission and quality traceability of Chinese herbs and their products in the whole production process.

关 键 词：头痛方 正交试验 水提工艺 高效液相色谱法 主成分分析 质量追溯 

分 类 号：R943[医药卫生—药剂学] R932[医药卫生—药学] R284.1