倍他司汀联合丁咯地尔治疗眩晕综合征临床研究  

Clinical Study of Betahistine Combined with Buflomedil in the Treatment of Vertigo Syndrome

作　　者：林雅明 周辉[1] 吴云虹[1] LIN Yaming;ZHOU Hui;WU Yunhong(Department of Neurology,Sanya People's Hospital,Sanya,Hainan,China 572000)

机构地区：[1]海南省三亚市人民医院神经内科,海南三亚572000

出　　处：《中国药业》2022年第16期97-100,共4页China Pharmaceuticals

基　　金：海南省自然科学基金面上项目[818MS173]。

摘　　要：目的探讨倍他司汀联合丁咯地尔治疗眩晕综合征的临床疗效及对患者血流动力学指标的影响。方法选取医院2018年1月至2021年1月收治的眩晕综合征患者120例,按随机抽样法分为观察组和对照组,各60例。两组患者均给予盐酸丁咯地尔注射液静脉滴注,观察组患者加服盐酸倍他司汀片,均以2周为1个疗程,治疗3个疗程。结果观察组总有效率为91.67%,显著高于对照组的73.33%(P<0.05)。治疗后,观察组患者的眩晕症状评分简化量表、眩晕障碍量表评分均显著低于对照组,Berg平衡量表评分显著高于对照组(P<0.05);观察组患者的全血高切黏度和红细胞比容均显著低于对照组,椎动脉、基底动脉血流速率均显著高于对照组(P<0.05);观察组患者的神经烯醇化酶、脂肪酸结合蛋白、微管相关蛋白水平均显著低于对照组(P<0.05)。治疗期间,观察组与对照组不良反应发生率相当(13.33%比8.33%,P>0.05)。结论倍他司汀联合丁咯地尔治疗眩晕综合征,可改善患者的眩晕症状、血流动力学指标,降低脑损伤标志物水平。Objective To investigate the clinical efficacy of betahistine combined with buflomedil in the treatment of vertigo syndrome and its effect on hemodynamic indexes.Methods A total of 120 patients with vertigo syndrome treated in the hospital from January 2018 to January 2021 were selected and divided into the observation group and the control group by the random sampling method,with 60 cases in each group.The patients in the two groups were given an intravenous drip of Buflomedil Hydrochloride Injection,on this basis,the patients in the observation group were given Betahistine Hydrochloride Tablets.Both groups were treated for three courses with two weeks as a course of treatment.Results The total effective rate in the observation group was 91.67%,which was significantly higher than 73.33% in the control group(P<0.05).After treatment,the scores of Vertigo Symptom Scale Short Form(VSS-SF)and Dizziness Handicap Index(DHI)in the observation group were significantly lower than those in the control group,while the score of Berg Balance Scale(BBS)in the observation group was significantly higher than that in the control group(P<0.05).The high-shear blood viscosity(HBV)and hematocrit(Hct)in the observation group were significantly lower than those in the control group,while the blood flow velocities of the vertebral artery and basilar artery in the observation group were significantly higher than those in the control group(P<0.05).The levels of neuron-specific enolase(NSE),heart-type fatty-acid binding protein(H-FABP),and microtubule-associated protein(Tau)in the observation group were significantly lower than those in the control group(P<0.05).During the treatment,the incidence of adverse drug reactions in the observation group was similar to that in the control group(13.33%vs.8.33%,P>0.05).Conclusion Betahistine combined with buflomedil in the treatment of vertigo syndrome can improve vertigo symptoms and hemodynamic indexes,and reduce the level of brain injury markers.

关 键 词：眩晕综合征 丁咯地尔 倍他司汀 临床疗效 血流动力学 眩晕症状评分 

分 类 号：R969.4[医药卫生—药理学] R97[医药卫生—药学]