1型糖尿病合并抑郁症状患者核因子κB表达的变化  

The expression variance of nuclear factor kappa B in Type 1 diabetes mellitus patients complicated with depressive symptoms

作　　者：林晓仪[1] 叶凯云[1] 梁干雄[1] Lin Xiaoyi;Ye Kaiyun;Liang Ganxiong(Department of endocrinology,the people's hospital of Zhongshan city,Zhongshan,Guangdong,528403,China.)

机构地区：[1]中山市人民医院内分泌科,广东中山528400

出　　处：《齐齐哈尔医学院学报》2022年第11期1001-1007,共7页Journal of Qiqihar Medical University

基　　金：中山市卫生健康局医学科研项目(2019J020)。

摘　　要：目的探讨1型糖尿病(T1DM)合并抑郁症状患者外周血核因子κB(NF-κB)等炎症因子表达的变化。方法收集2019年1—7月本院登记的广东省中山市T1DM患者的临床资料。经纳入及排除标准筛选后符合条件者以SDS量表评估抑郁症状,分为无抑郁症状组(n=50)及抑郁症状组(n=32)两组。血清中NF-κB及肿瘤坏死因子α(TNF-α)采用酶联免疫吸附法测定。以Logistic回归法分析T1DM合并抑郁症状的影响因素。随后以T1DM合并抑郁症状组患者为研究对象,进行包括心理干预的规范化治疗,治疗6个月后再次进行NF-κB及TNF-α的测定。结果T1DM患者中抑郁症状组血清总胆固醇、低密度脂蛋白胆固醇、NF-κB及TNF-α的水平均高于无抑郁症状组(P均<0.05),NF-κB与LDLC是抑郁症状的危险因素(OR分别为2.318及1.007,P均<0.05)。进行包括心理干预的规范化治疗6个月后SDS评分、NF-κB及TNF-α的水平均低于治疗前(P均<0.05)。结论T1DM合并抑郁症状患者NF-κB表达升高,经包括心理干预的规范化治疗后NF-κB降低,NF-κB与T1DM合并抑郁症状相关。Objective To investigate the changes of inflammatory factors such as nuclear factorκB(NF-κB)in patients with type 1 diabetes mellitus(T1DM)combined with depressive symptoms.Methods Clinical information was collected from T1DM patients in Zhongshan city of Guangdong province those were registered in our hospital from January to July of 2019.Those patients who met the enrolling criteria were assessed by Self-rating Depression Scale(SDS)and they were divided into non-depressive symptoms group(n=50)and depressive symptoms group(n=32).Serum NF-κB and tumor necrosis factor-α(TNF-α)were assayed by enzyme linked immunosorbent assay.Logistic regression analysis was adopted to assess the impact factors of depressive symptoms.Then,the patients suffered with T1DM combined with depressive symptoms were treated with standardized treatment including psychological intervention.NF-κB and TNF-αwere assayed again after 6 months of treatment.Results The levels of total cholesterol,low density lipoprotein cholesterol(LDLC),serum NF-κB and TNF-αin T1DM with depressive symptoms group were higher than those in non-depressive symptoms group(all P<0.05).Logistic regression analysis indicated that NF-κB and LDLC were risk factors of depressive symptoms in T1DM patients(OR=2.318 and 1.007,all P<0.05).After 6 months of standardized treatment including psychological intervention,the SDS scores,serum NF-κB and TNF-αin T1DM with depressive symptoms group were lower than those before treatment(all P<0.05).Conclusions The T1DM patients with depressive symptoms had higher expression level of NF-κB,and it decreases after standardized treatment including psychological intervention.NF-κB is correlated with T1DM patients with depressive symptoms comorbidity.

关 键 词：1型糖尿病 抑郁症状 核因子-ΚB 肿瘤坏死因子-Α 

分 类 号：R587.1[医药卫生—内分泌]