创面愈合中力学刺激对巨噬细胞极化调控作用的研究进展  

Research progress on the regulation of macrophage polarization by mechanical stimulation in wound healing

作　　者：许晨露 余丹[1] 朱慧勇[1] XU Chenlu;YU Dan;ZHU Huiyong(Department of Stomatology,the First Affiliated Hospital of Medical College of Zhejiang University,Hangzhou Zhejiang,310003,P.R.China;Medical College of Zhejiang University,Hangzhou Zhejiang,310030,P.R.China)

机构地区：[1]浙江大学医学院附属第一医院口腔科,杭州310003 [2]浙江大学医学院,杭州310030

出　　处：《中国修复重建外科杂志》2022年第8期1041-1046,共6页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：浙江省基础公益研究计划(LGF20H140007);浙江省医药卫生科技计划项目青年人才计划(2019RC151)。

摘　　要：目的 综述创面愈合中力学刺激对巨噬细胞极化的调控作用,探讨力学刺激在组织工程中的应用前景。方法 广泛查阅近年来国内外相关文献,分析巨噬细胞不同表型及其在创面愈合中的作用、力学刺激在巨噬细胞表型转化中的调控作用,并探讨组织工程中利用力学刺激调控巨噬细胞极化的可能性。结果 巨噬细胞具有功能多样性,有促炎型(M1型)和抗炎型(M2型)两种表型,不同环境刺激下巨噬细胞呈现不同的活化表型并发挥相应功能。不同类型、大小及振幅的机械力可直接或间接引导巨噬细胞向不同表型转化,进而影响组织修复,组织工程可利用这一特点选择性调控巨噬细胞极化。结论 创面愈合中力学刺激对巨噬细胞极化的调控起重要作用,但具体作用及其机制尚不明确,仍待进一步研究。Objective To summary the regulatory effect of mechanical stimulation on macrophage polarization in wound healing, and explore the application prospect of mechanical stimulation in tissue engineering. Methods The related domestic and foreign literature in recent years was extensive reviewed, and the different phenotypes of macrophages and their roles in wound healing, the effect of mechanical stimulation on macrophage polarization and its application in tissue engineering were analyzed. Results Macrophages have functional diversity, with two phenotypes:pro-inflammatory(M1 type) and anti-inflammatory(M2 type), and the cells exhibit different activation phenotypes and play corresponding functions under different stimuli. The mechanical force of different types, sizes, and amplitudes can directly or indirectly guide macrophages to transform into different phenotypes, and then affect tissue repair. This feature can be used in tissue engineering to selectively regulate macrophage polarization. Conclusion Mechanical stimulation plays an vital role in regulating macrophage polarization, but its specific role and mechanism remain ambiguous and need to be further explored.

关 键 词：巨噬细胞 极化 力学刺激 创面愈合 组织工程 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]