微量元素、维生素在腹泻型肠易激综合征儿童中的水平及意义  

The level and significance of trace elements and vitamins in children with diarrhea-predominant irritable bowel syndrome

作　　者：付小梅 陈秋月 段光敏[1] 黄晓玲[1] FU Xiaomei;CHEN Qiuyue;DUAN Guangmin;HUANG Xiaoling(Department of Pediatrics,Neijiang first people's Hospital,Sichuan Neijiang 646000,China)

机构地区：[1]内江市第一人民医院儿科,四川内江646000

出　　处：《中国妇幼健康研究》2022年第7期94-97,共4页Chinese Journal of Woman and Child Health Research

摘　　要：目的检测腹泻型肠易激综合征(IBS-D)患儿的微量元素、维生素含量,并探讨其临床意义。方法随机抽取2019年1月至2020年8月内江市第一人民医院收治的86例IBS-D患儿为观察组,同一时期该院健康体检者86例为对照组,分析并比较两组锌(Zn)、铁(Fe)、铜(Cu)、镁(Mg)、锰(Mn)、硒(Se)等微量元素,以及维生素(V)A、VB1、VB2、VB6、VC、VE、25(OH)VD、叶酸水平。结果两组血清Mn、Mg、Se水平比较差异无统计学意义(P>0.05);观察组血清Fe、Zn水平低于对照组,Cu水平高于对照组,差异均有统计学意义(t值分别为6.805、5.637、5.489,P<0.05);观察组患儿血清VB1、VC、25(OH)VD水平均低于对照组,差异有统计学意义(t值分别为4.568、5.851、6.553,P<0.05);两组血清VA、VB2、VB6、VE和叶酸水平比较差异无统计学意义(P>0.05);IBS-D患儿血清Zn、Fe、Cu、VB1、VC、25(OH)VD水平与性别、年龄、体质量指数(BMI)均无显著相关性(P>0.05)。结论IBS-D患儿体内易缺乏锌、铁等微量元素和维生素B1、维生素C、维生素D,维持血清微量元素和维生素的平衡,可能对腹泻型肠易激综合征有一定的临床意义。Objective To detect the content of trace elements and vitamins in children with diarrhea-predominant irritable bowel syndrome(IBS-D),and to explore its clinical significance.Methods A random sample of 86 children with IBS-D admitted to the First People′s Hospital of Neijiang City from January 2019 to August 2020 were selected as the observation group,and 86 healthy patients in this hospital during the same period were selected as the control group.The levers of zinc(Zn),ferrum(Fe),cuprum(Cu),magnesium(Mg),manganese(Mn),selenium(Se)and other trace elements,as well as vitamins(V)A,VB1,VB2,VB6,VC,VE,25(OH)VD and folic acid of two groups were analyzed and compared.Results There was no significant difference in serum Mn,Mg,and Se levels between the two groups(P>0.05).The observation group′s serum Fe and Zn levels were lower than the control group,and the Cu levels were higher than the control group.The differences were statistically significant(t=6.805,5.637 and 5.489,respectively,P<0.05).The levels of serum VB1,VC,and 25(OH)VD in the observation group were lower than those in the control group,and the difference was statistically significant(t=4.568,5.851 and 6.553,respectively,P<0.05).There was no significant difference in serum VA,VB2,VB6,VE and folic acid levels between the two groups(P>0.05);There was no significant correlation between serum Zn,Fe,Cu,VB1,VC,25(OH)VD levels and gender,age,body mass index(BMI)in children with IBS-D(P>0.05).Conclusion Children with IBS-D tend to be deficient in trace elements such as zinc and iron,vitamin B1,vitamin C,and vitamin D.Maintaining the balance of serum trace elements and vitamins may have certain clinical significance for IBS-D.

关 键 词：腹泻型肠易激综合征 微量元素 维生素 诊断价值 

分 类 号：R179[医药卫生—妇幼卫生保健]