8-异前列腺素F2α和白细胞介素-17预测慢性阻塞性肺疾病稳定期患者急性发作的作用  

Research on serum 8-iso-PGF2α and IL-17 levels in the prediction of times of acute attacks in patients with stable chronic obstructive pulmonary disease within one year

作　　者：李建英 刘远程 潘杨 LI Jian-ying;LIU Yuan-cheng;PAN Yang(Department of Respiratory Medicine,Civil Aviation General Hospital,Beijing 100123,China)

机构地区：[1]北京大学民航临床医学院(民航总医院)呼吸内科,北京100123

出　　处：《医学研究生学报》2022年第8期863-867,共5页Journal of Medical Postgraduates

基　　金：民航总医院院级项目(20200414)。

摘　　要：目的 当前利用血清白细胞介素-17(IL-17)、8-异前列腺素F2α(8-iso-PGF2α)与炎症及氧化应激关系推测慢性阻塞性肺疾病(COPD)稳定期患者急性发作次数的研究鲜有报道。文中分析8-iso-PGF2α、IL-17对COPD稳定期患者一年内急性发作次数的预测价值。方法 回顾性分析2018年1月-2020年12月于北京大学民航临床医学院完成治疗及随访的140例出院后一年内急性发作次数≥2次的COPD稳定期患者病历资料(频发组);另收集同期于本院完成治疗及随访的140例一年内急性发作次数为≤1次的COPD稳定期患者资料(非频发组)。查阅并记录患者基线资料及实验室指标,记录出院时血清8-iso-PGF2α、IL-17水平,分析;两者预测COPD稳定期患者一年内急性发作次数≥2的价值。结果 频发组患者血清8-iso-PGF2α、IL-17、CRP、IL-6水平高于非频繁发作组(P<0.05)。Logistic回归分析结果显示,血清8-iso-PGF2α、IL-17、CRP、IL-6过表达均与COPD稳定期患者一年内急性发作次数有关,可能是患者频繁急性发作的风险因子(OR>1,P<0.05)。绘制ROC曲线结果显示,出院时血清8-iso-PGF2α、IL-17单独及联合预测COPD稳定期患者频繁急性发作风险的AUC均>0.8,有一定预测价值;相关性检验发现,血清8-iso-PGF2α、IL-17水平之间呈正相关(r_(s)>0,P<0.001)。结论 COPD稳定期出院时血清8-iso-PGF2α、IL-17过表达可能与一年内急性发作次数有关,对预测一年内急性发作次数有一定价值。入院时两者过表达可能提示频繁急性发作高风险。Objective To observe the expression of serum 8-iso prostaglandin F2α(8-iso-PGF2α) and IL-17 in patients with stable chronic obstructive pulmonary disease(COPD), and to analyze the value of the two in predicting the times of acute attacks in patients within 1 year. Methods A retrospective analysis was performed, the clinical data of 140 patients with stable COPD who had completed treatment and follow-up and the times of acute attacks ≥2 within 1 year after discharge in our hospital from January 2018 to December 2020 were collected, set them as the frequent attack group;in addition, 140 patients with stable COPD who had completed treatment and follow-up and the times of acute attacks ≤1 within 1 year after discharge at the same period were selected, set them as the non frequent attack group;the follow-up date was until December 30, 2020;the baseline data and laboratory parameters of patients were consulted and recorded, the serum 8-iso-PGF2α and IL-17 levels at the time of discharge were mainly recorded, the value of the two in predicting times of acute attacks ≥2 in stable COPD patients within 1 year was analyzed. Results The serum 8-iso-PGF2α, IL-17, CRP and IL-6 levels of patients in frequent attack group were higher than those in non frequent attack group(P<0.05);the results of Logistic regression analysis showed that the overexpression of serum 8-iso-PGF2α, IL-17, CRP and IL-6 was associated with times of acute attacks in stable COPD patients within 1 year, which might be the risk factor of frequent acute attack(OR>1, P<0.05);the ROC curve was drawn, and the results showed that the AUC of serum 8-iso-PGF2α and IL-17 alone or combined to predict the risk of frequent acute attack in stable COPD patients at the time of discharge were >0.80, which had certain predictive value;correlation test showed that there was a positive correlation between serum 8-iso-PGF2α and IL-17 levels(rs>0, P<0.001). Conclusion The overexpression of serum 8-iso-PGF2α and IL-17 at the time of discharge in stable COPD may be

关 键 词：慢性阻塞性肺疾病 稳定期 8-异前列腺素F2Α 白细胞介素-17 急性发作 预测 

分 类 号：R563[医药卫生—呼吸系统]