驱避剂安全性研究进展  

Research progress on safety of repellents

作　　者：张婉莉 彭恒 单文琪 马雅军 ZHANG Wan-li;PENG Heng;SHAN Wen-qi;MA Ya-jun(College of Naval Medicine,Naval Medical University,Shanghai 200433,China;College of Basic Medicine,Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学海军医学系,上海200433 [2]海军军医大学基础医学院,上海200433

出　　处：《中国媒介生物学及控制杂志》2022年第4期601-607,共7页Chinese Journal of Vector Biology and Control

基　　金：国家自然科学基金(31970445);上海市自然科学基金(19ZR1469600);后勤科研课题重大项目(ALB19J003);学员创新实践课题(HL21JD1218)。

摘　　要：驱避剂通过影响嗅觉系统对吸血昆虫产生驱避作用,减少叮咬,从而预防虫媒病的发生。驱避剂在推荐剂量下使用应是安全的。然而随着长期观察数据的累积,驱避剂引起的毒性案例受到广泛关注,如避蚊胺引起儿童中毒性脑病,氯菊酯导致哮喘样过敏性反应等。因此,总结驱避剂产生的长期毒性,并深入研究其机制,为研发更安全的驱避剂提供理论依据,具有重要的科学和应用价值。该文综述了当前主要应用的驱避剂安全性事件以及机制研究的最新进展,思考了驱避剂的发展趋势和研究方向。Repellents can repel blood-sucking insects and reduce bites by affecting their olfactory system,thus preventing the occurrence of insect-borne diseases.Repellents are widely used because of their safety at the recommended dose.However,with the long-term accumulation of observation data,the toxicity cases caused by repellents have attracted extensive attention,such as toxic encephalopathy in children induced by diethyltoluamide and asthma-like allergic reaction induced by permethrin.Therefore,summarizing the long-term toxicity of repellents and deeply exploring the intrinsic mechanism provide a theoretical basis for the development of safer repellents and have an important scientific and application value.This paper reviews the latest progress of studies on safety events and mechanisms of currently applied major repellents,and considers the development trend and research direction of repellents.

关 键 词：驱避剂 天然驱避剂 合成驱避剂 毒性 避蚊胺 氯菊酯 

分 类 号：S852.7[农业科学—基础兽医学]