骨植入用铸态Mg-Ga合金的力学性能、生物降解行为及细胞相容性  

Mechanical Properties,Biodegradation Behavior,and Cytocompatibility of As-Cast Mg-Ga Alloys for Bone Implant Applications

作　　者：高静如 何东磊 郭佳乐 薛贤达 毕衍泽 李岩[1,2,3,4] 郑洋[5] 于宏燕 Gao Jingru;He Donglei;Guo Jiale;Xue Xianda;Bi Yanze;Li Yan;ZhengYang;Yu Hongyan(School of Materials Science and Engineering,Beihang University,Beijing 100191,China;Beijing Advanced Innovation Center for Biomedical Engineering,Beihang University,Beijing 100191,China;Key Laboratory of Aerospace Advanced Materials and Performance,Ministry of Education,Beihang University,Beijing 100191,China;Hangzhou Innovation Institute,Beihang University,Hangzhou 310023,China;School of Mechanical Engineering,Tiangong University,Tianjin 300387,China;Beijing Key Laboratory of Radiation Advanced Materials,Beijing Research Center for Radiation Application,Beijing 100015,China)

机构地区：[1]北京航空航天大学材料科学与工程学院,北京100191 [2]北京航空航天大学北京生物医学工程高精尖创新中心,北京100191 [3]北京航空航天大学空天先进材料与服役教育部重点实验室,北京100191 [4]北京航空航天大学杭州创新研究院,浙江杭州310023 [5]天津工业大学机械工程学院,天津300387 [6]北京市射线应用研究中心辐射新材料北京市重点实验室,北京100015

出　　处：《稀有金属材料与工程》2022年第7期2379-2386,共8页Rare Metal Materials and Engineering

基　　金：National Natural Science Foundation of China (51971014);Tianjin Municipal Natural Science Foundation (19JCQNJC02800);Beijing Municipal Natural Science Foundation (2182021)。

摘　　要：研究了铸态Mg-2Ga和Mg-5Ga合金的力学性能、生物腐蚀行为、细胞相容性与其微观组织结构的变化关系。采用X射线衍射仪(XRD)和扫描电子显微镜(SEM)对材料的微观组织结构进行了分析。结果表明:添加Ga元素后,在镁基体的晶界上形成了球状和带状的Mg_(5)Ga_(2)析出相,Ga元素显著细化了镁基体的晶粒尺寸。力学拉伸试验结果表明,Ga元素可通过固溶强化、晶界强化、析出强化等作用提高Mg-Ga合金的力学性能。在37℃模拟体液中的电化学腐蚀和浸泡腐蚀试验结果表明,低Ga含量能够提高Mg-Ga合金的表面稳定性,从而改善其腐蚀行为。此外,间接接触细胞培养试验结果表明,Mg-2Ga与Mg-5Ga合金均对小鼠成纤维细胞(L929)表现出良好的细胞相容性,未对其产生明显的细胞毒性。The microstructures, mechanical properties, biodegradation behavior, and cytocompatibility of the as-cast Mg-2Ga and Mg-5Ga alloys were investigated. The microstructure characteristics were studied by X-ray diffractometer(XRD) and scanning electron microscopy(SEM). The results show that the Mg_(5)Ga_(2)precipitates with globular and strip-like shapes are formed along the grain boundaries in Mg matrix after Ga addition. The grains of Mg-Ga alloys are obviously refined by Ga addition. The tensile tests reveal that the mechanical properties of Mg-Ga alloys are enhanced by Ga addition via solution strengthening, grain boundary strengthening, and precipitation strengthening. The electrochemistry and immersion corrosion tests in simulated body fluid at 37 ℃ reveal that the improved corrosion behavior is attributed to the enhanced surface stability caused by Ga addition of low content. In addition, the indirect contact assay suggests that both Mg-2Ga and Mg-5Ga alloys exhibit favorable cytocompatibility with no cytotoxicity for the mouse fibroblast(L929) cells.

关 键 词：生物降解金属 镁稼合金 力学性能 生物降解行为 细胞相容性 

分 类 号：TG146.22[一般工业技术—材料科学与工程] R318.08[金属学及工艺—金属材料]