中医药调控线粒体自噬防治慢性肾脏病的研究进展  

Research progress on regulation of mitophagy by traditional Chinese medicine in prevention and treatment of chronic kidney diseases

作　　者：金丽霞[1] 张晓东[2] 潘超 赵文卓 栾仲秋[1] 隋艳波[1] JIN Li-xia;ZHANG Xiao-dong;PAN Chao;ZHAO Wen-zhuo;LUAN Zhong-qiu;SUI Yan-bo(First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Heilongjiang University of Chinese Medicine,Harbin 150006,China)

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040 [2]黑龙江中医药大学,黑龙江哈尔滨150006

出　　处：《中国中药杂志》2022年第13期3432-3438,共7页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金青年基金项目(81904107);黑龙江省自然科学基金面上项目(H2016066);黑龙江省中医药学会青年中医药科技创新项目(ZHY19-023)。

摘　　要：慢性肾脏病(chronic kidney disease,CKD)患病率逐年上升,已经成为高度流行的疾病,严重影响患者的生活质量,并造成家庭负担。引起慢性肾脏病的疾病很多,主要包括各种原发的以及继发的肾小球肾炎、肾小管损伤和肾血管的病变等。常规内科治疗虽在一定程度上可以缓解临床症状,但有时仍难阻止CKD的进展。中医药治疗CKD具有安全性较高,不良反应较少的特点,且临床疗效肯定,其活性成分可以通过多途径、多靶点发挥协同作用,延缓疾病进展,但其作用机制尚未完全阐明。通过回顾和研究该领域的国内外文献发现,线粒体自噬异常是不同形式肾脏疾病发病机制的共同特征。近年来,已有大量实验研究证明通过PINK1/Parkin信号通路和线粒体自噬受体途径调控线粒体自噬可延缓CKD的进展,保护肾功能。因此中医药通过相关途径调控线粒体自噬防治CKD成为近年来非常有潜力的治疗靶点。该文收集中医药通过相关途径调控线粒体自噬在防治CKD方面具有明确疗效的文献,以期为防治CKD,延缓其进入终末期肾脏病提供新靶点和新策略。The prevalence of chronic kidney disease(CKD)increases year by year and has become a highly prevalent disease,seriously affecting the quality of life of patients and bringing heavy family burden.There are many diseases causing CKD,including va-rious primary and secondary glomerulonephritis,renal tubular injury,and renal vascular lesions.Although routine medical treatment for CKD can alleviate the clinical symptoms to a certain extent,it is sometimes difficult to prevent the progression of CKD.Traditional Chinese medicine(TCM)is advantageous in high safety,few adverse reactions,and definite clinical efficacy in the treatment of CKD.The active components contained can play a synergistic effect through multiple pathways and multiple targets to delay disease progression,but its mechanism of action has not been fully elucidated.As revealed by the literature in this field in China and abroad,abnormal mitophagy is a common feature of the pathogenesis of CKD of different types.In recent years,a large number of studies have proved that the regulation of mitophagy through the PINK1/Parkin signaling pathway and mitophagy receptor pathway could delay the progression of CKD and protect renal function.Therefore,the regulation of mitophagy by TCM in the prevention and treatment of CKD through related pathways has become a potential therapeutic target in recent years.This paper reviewed the research articles on the definite efficacy of TCM in preventing and treating CKD by regulating mitophagy through relevant pathways to provide new targets and stra-tegies for preventing and treating CKD and delaying their entry into end-stage renal diseases.

关 键 词：慢性肾脏病 线粒体自噬 PINK1/Parkin 线粒体自噬受体 糖尿病肾病 药物性肾损伤 

分 类 号：R277.5[医药卫生—中医学]