孕康糖浆联合烯丙雌醇治疗先兆流产的临床研究  

Clinical study on Yunkang Syrup combined with allylestrenol in treatment of threatened abortion

作　　者：葛冰冰 孔双 GE Bing-bing;KONG Shuang(Department of Obstetrics and Gynecology,the First People’s Hospital of Ruzhou,Pingdignshan 467500,China;Maternity Ward,Anyang Maternal and Child Health Care Hospital,Anyang 455000,China)

机构地区：[1]汝州市第一人民医院妇产科,河南平顶山467500 [2]安阳市妇幼保健院产科病区,河南安阳455000

出　　处：《现代药物与临床》2022年第7期1579-1583,共5页Drugs & Clinic

基　　金：安阳市重点研发与推广专项(2022C01SF049)。

摘　　要：目的探讨孕康糖浆联合烯丙雌醇片治疗先兆流产的临床疗效。方法选取2019年10月—2021年10月在汝州市第一人民医院就诊的138例先兆流产患者,按照随机数字表法将所有患者分为对照组和治疗组,每组各69例。对照组口服烯丙雌醇片,孕周6~8周,5 mg/次,1次/12 h;孕周9~12周,10 mg/次,1次/12 h。治疗组在对照组基础上口服孕康糖浆,20 mL/次,3次/d。两组连续治疗14 d。观察两组的临床疗效,比较两组症状的消失时间和血清中β人绒毛膜促性腺激素(β-HCG)、泌乳素(PRL)、妊娠相关蛋白A(PAPP-A)、激活素A、抑制素A、糖类抗原125(CA125)水平。结果治疗后,治疗组患者的总有效率为95.65%,对照组的总有效率为84.06%,组间有明显差异(P<0.05)。治疗后,治疗组阴道出血、下腹痛、腰酸胀痛消失时间比对照组短,差异有统计学意义(P<0.05)。治疗后,两组的β-HCG、PRL、PAPP-A水平显著升高(P<0.05),治疗组β-HCG、PRL、PAPP-A水平显著高于对照组,差异有统计学意义(P<0.05)。治疗后,两组的血清激活素A、抑制素A水平明显升高,CA125水平明显降低(P<0.05);治疗后治疗组的血清激活素A、抑制素A水平高于对照组,CA125水平低于对照组,差异有统计学意义(P<0.05)。结论孕康糖浆联合烯丙雌醇片可提高先兆流产的临床疗效,有助于进一步减轻临床症状,调节激素水平,调节激活素A、抑制素A、CA125水平,安全性较好。Objective To investigate the therapeutic effect of Yunkang Syrup combined with Allylestrenol Tablets in treatment of threatened abortion.Methods Patients(138 cases)with threatened abortion in the First People’s Hospital of Ruzhou from October 2019 to October 2021 were randomly divided into control and treatment groups,and each group had 69 cases.Patients in the control group were po administered with Allylestrenol Tablets,pregnant weeks:6—8 weeks,5 mg/time,every 12 h,pregnant weeks:9—12 weeks,10 mg/time,every 12 h.Patients in the treatment group were po administered with Yunkang Syrup on the basis of the control group,20 mL/time,three times daily.Patients in two groups were treated for 14 d.After treatment,the clinical efficacies were evaluated,and the disappearance time of symptoms,the serum levels ofβ-hCG,PRL,PAPP-A,activin A,inhibin A,and CA125 in two groups were compared.Results After treatment,the total effective rate was 95.65%in the treatment group,84.06%in the control group,and there was significant difference between the groups(P<0.05).After treatment,the disappearance time of vaginal bleeding,lower abdominal pain,and low back pain in the treatment group was shorter than that in the control group(P<0.05).After treatment,the levels ofβ-hCG,PRL,and PAPP-A in two groups were significantly increased(P<0.05).And the levels ofβ-hCG,PRL,and PAPP-A in the treatment group were significantly higher than those in the control group(P<0.05).After treatment,activin A and inhibin A in two groups were significantly increased,but the level of CA125 were significantly decreased(P<0.05).After treatment,the levels of activin A and inhibin A in the treatment group were higher than those in the control group,but the level of CA125 was lower than that in the control group(P<0.05).Conclusion Yunkang Syrup combined with Allylestrenol Tablets can improve the clinical efficacy of threatened abortion,help to further reduce clinical symptoms,regulate hormone levels,and regulate the levels of activin A,inhibin A and CA125,wi

关 键 词：孕康糖浆 烯丙雌醇片 先兆流产 Β人绒毛膜促性腺激素 泌乳素 激活素A 抑制素A 糖类抗原125 

分 类 号：R984[医药卫生—药品]