白细胞介素11在特发性肺纤维化中的研究进展  

Research progress of interleukin-11 in idiopathic pulmonary fibrosis

作　　者：李占霞 任涛[1] Li Zhanxia;Ren Tao(Department of Respiratory and Critical Care Medicine,the Sixth People's Hospital affiliated to Shanghai Jiao Tong University,Shanghai 200233,China)

机构地区：[1]上海交通大学附属第六人民医院呼吸与危重症医学科,上海200233

出　　处：《国际呼吸杂志》2022年第15期1186-1189,共4页International Journal of Respiration

基　　金：国家自然科学基金(82104771);上海交通大学医工交叉研究基金项目(YG2021QN94)。

摘　　要：白细胞介素11(IL-11)最初被认为是一种免疫调节和造血诱导细胞因子。但越来越多的研究提示IL-11可能在肺纤维化中发挥了重要作用。以IL-11为靶点的治疗策略,例如人源化抗体的出现,初步揭示了IL-11在肺纤维化中的治疗潜力。因此,进一步深入了解IL-11在特发性肺纤维化中的作用及机制,可为其在临床中治疗特发性肺纤维化提供更多的理论基础和依据。现对IL-11在肺中的表达和作用机制进行概述,并重点关注其在肺纤维化中的作用及其作为治疗靶点的潜力。Interleukin 11(IL-11)was firstly identified as an immunomodulatory and hematopoietic inducing cytokine,while recent researches suggest that IL-11 may be significantly effective in pulmonary fibrosis.Therapeutic strategies in which IL-11 service as the target involving the advent of humanized antibodies initially reveal the therapeutic potential of IL-11 in pulmonary fibrosis.Therefore,further understandings on the effects and mechanism of IL-11 in idiopathic pulmonary fibrosis(IPF)supports providing more theoretical foundation&basis for its clinical treatment of IPF.Expression and mechanism of action of IL-11 in the lungs is overviewed presently,and corresponding effects in pulmonary fibrosis and potential as a therapeutic target are specially focused on.

关 键 词：特发性肺纤维化 白细胞介素11 信号传导 治疗靶点 

分 类 号：R563[医药卫生—呼吸系统]