纳米氟羟基磷灰石的制备及应用研究进展  

Progress on preparation and application of nano-sized fluorinated hydroxyapatite

作　　者：王国霞 陕绍云[1] 支云飞 苏红莹[1] 胡天丁 张楚茹 Wang Guoxia;Shan Shaoyun;Zhi Yunfei;Su Hongying;Hu Tianding;Zhang Churu(College of Chemical Engineering,Kunming University of Science and Technology,Kunming 650504)

机构地区：[1]昆明理工大学化学工程学院,昆明650504

出　　处：《化工新型材料》2022年第7期235-240,共6页New Chemical Materials

基　　金：国家自然科学基金(21766016);云南省“万人计划”基金项目(YNWR-QNBJ-2018-198);昆明市科学技术局科技计划基金项目(2019-1-G-25318000003480);倪永浩院士工作站(2019IC002)。

摘　　要：氟是人体中不可缺少的元素之一,羟基磷灰石(HAP)中的部分羟基离子被氟离子取代后形成氟羟基磷灰石(FHA)。氟离子取代羟基离子进入HAP的晶体结构,不会改变HAP的基本结构,但可以使其更加稳定,进而改良溶解度过高的缺陷。并且引入氟离子能够刺激骨细胞生长,起到促进骨结合的作用。介绍了纳米FHA的制备方法的优缺点及其研究进展,为未来合成性能更优良的FHA材料提供参考。此外,还综述了FHA在生物医疗领域中的应用和发展前景。Fluorine is one of the indispensable elements in human body.Some OH^(-) in hydroxyapatite [HAP,Ca_(10)(PO_(4))_(6)(OH)_(2)] are replaced by F^(-) to form fluorinated hydroxyapatite [FHA,Ca_(10)(PO_(4))_(6)(OH)_(2-x)F_(x)].F^(-) replacing the original OH^(-) incorporates into the crystal structure of HAP,which will not change its basic structure,but make HAP more stable and improve the defects of high solubility.Moreover,the growth of bone cells and promote bone union can be stimulated by the F^(-).The advantages and disadvantages of the preparation methods of nano-FHA and its research progress were introduced,providing a reference for the synthesis of better FHA materials in the future.In addition,the application and development prospect of FHA in biomedical field were also reviewed.

关 键 词：氟羟基磷灰石 生物医疗 骨增殖和分化 骨移植 骨质疏松 

分 类 号：TQ170[化学工程—硅酸盐工业]