嘉兴地区5岁以下儿童轮状病毒腹泻的疾病负担  

Disease burden of rotavirus diarrhea among children under 5 years old in Jiaxing

作　　者：甘正凯 何寒青[2] 周建红[1] 张艳[1] 沈月根[1] 吕华坤[2] Gan Zhengkai;He Hanqing;Zhou Jianhong;Zhang Yan;Shen Yuegen;Lyu Huakun(Department of Infectious Disease Control and Prevention,Xiuzhou District Center for Disease Control and Prevention,Jiaxing 314031,China;Institute of Immunization Program,Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China)

机构地区：[1]嘉兴市秀洲区疾病预防控制中心传染病防制科,嘉兴314031 [2]浙江省疾病预防控制中心免疫规划所,杭州310051

出　　处：《国际流行病学传染病学杂志》2022年第1期22-26,共5页International Journal of Epidemiology and Infectious Disease

基　　金："重大新药创制"科技重大专项(2018ZX09734004);秀洲区卫生系统主攻项目。

摘　　要：目的了解嘉兴地区5岁以下儿童轮状病毒腹泻疾病负担情况。方法采用系统抽样法,抽取2018—2019年嘉兴市秀洲区各乡镇/街道报告的300例5岁以下轮状病毒腹泻病例作为调查对象。采用自行设计的调查表,获取调查对象基本情况和治疗情况,以及生病期间亲属陪护情况和生命质量等情况,综合评估疾病负担。结果300例患儿的调查问卷中,共收集到中共295份有效问卷。295例患儿年龄为(1.35±1.07)岁,其中男性患儿168例(56.95%),门诊儿童病例265例(89.83%);总经济负担为505601.33元,人均总经济负担为1713.90元,人均直接和间接经济负担分别为1359.23和354.67元。不同性别、年龄、居住地病例直接、间接、总经济负担之间的差异均无统计学意义(P均>0.05),住院病例直接、间接、总经济负担的中位数分别为6178.66、1188.04和7696.04元,均高于门诊病例(Z=-8.98,-8.77和-8.98,P均<0.001)。调查对象损失的伤残调整生命年为0.34人年,负担强度中位数为每千人口1.19人年,不同年龄病例间的负担强度差异有统计学意义(χ^(2)=77.22,P<0.001),其中4~<5岁组最大,为每千人口3.12人年,0~<1岁组最小,为每千人口0.30人年。结论嘉兴地区5岁以下儿童轮状病毒腹泻疾病负担整体较重,儿童年龄越大生命质量损失越高。Objective To understand the disease burden of rotavirus diarrhea among children under 5 years old in Jiaxing city.Methods A total of 300 rotavirus diarrhea cases under 5 years old who were reported by township or subdistrict from 2018 to 2019 in Xiuzhou District of Jiaxing were selected by system sampling method.The basic information and data on therapy,health care and life quality were investigated by self-designed questionnaires to comprehensively evaluate the disease burden.Results A total of 295 valid questionnaires were collected from 300 questionnaires.Among 295 investigated subjects,the age was(1.35±1.07)years.There were 168(56.95%)male cases and 265(89.83%)outpatients.The total economic burden was￥505601.33,and the mean economic burden was￥1713.90 per person.The mean direct and indirect economic burden were￥1359.23 and￥354.67 per person,respectively.The differences of the direct,indirect and total economic burden among rotavirus diarrhea cases with different genders,ages and places of residence was no statistically significant(P all>0.05).The median direct,indirect,and total economic burdens of hospitalized cases were￥6178.66,￥1188.04 and￥7696.04,which were all higher than those of outpatients,and the differences were statistically significant(Z=-8.98,-8.77 and-8.98,P all<0.001).The disability-adjusted life years(DALY)of 295 rotavirus diarrhea cases was 0.34,and the median burden strength was 1.19 per thousand.The difference of the burden strength among different age groups was statistically significant(χ^(2)=77.22,P<0.001).Group at 4-<5 years old showed the largest burden of 3.12 per thousand,while group at 0-<1 year old showed the least burden of 0.30 per thousand.Conclusions The disease burden of rotavirus diarrhea among children under 5 years old in Jiaxing city is heavy.As the children grow older,the loss of quality of life is higher.

关 键 词：轮状病毒 腹泻 疾病负担 伤残调整生命年 儿童 

分 类 号：R725.1[医药卫生—儿科]