新型冠状病毒感染的免疫记忆性  

Immune memory after SARS-CoV-2 infection

作　　者：李一唯 刘歌 赵巍[1] 王浩[1] Li Yiwei;Liu Ge;Zhao Wei;Wang Hao(School of Basic Medical Sciences,Ningxia Key Laboratory on Prevention and Treatment of Common Infectious Diseases,Ningxia Medical University,Yinchuan 750004,China;Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学基础医学院,宁夏常见传染病防治重点实验室,银川750004 [2]宁夏医科大学基础医学院生物化学与分子生物学系,银川750004

出　　处：《中华微生物学和免疫学杂志》2022年第7期527-534,共8页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金(82160691);宁夏自然科学基金(2020AAC03002);宁夏重点研发计划项目(2020BEG03060);国家级大学生创新创业训练计划项目(202010752001)。

摘　　要：COVID-19已成为严重的全球公共卫生事件,截至2022年6月25日,全球有超过5.4亿人确诊感染,累计死亡人数超过632万。了解COVID-19患者恢复后是否能获得持久免疫保护力是疫苗制备、疾病防控及判断疫情走向的关键。持久免疫保护力的产生核心是免疫记忆性,即针对新型冠状病毒产生有效免疫记忆。本文将围绕新型冠状病毒感染免疫记忆的生成与维持进行综述。The COVID-19 pandemic has become a serious global public health threat with more than 540 million infections and 6.32 million cases of death as of 25 June,2022.Understanding whether COVID-19 patients can obtain persistent immune protection after recovery is crucial for vaccine development,disease control and epidemic forecast.The persistent immunity against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection is mainly derived from the immune memory.Thus,the generation and maintenance of immune memory specifically targeted to the virus were reviewed in this paper.

关 键 词：新型冠状病毒 COVID-19 感染 免疫记忆性 

分 类 号：R563.1[医药卫生—呼吸系统]