低氧阈刺激促进神经干细胞增殖分化  

Hypoxia Threshold Stimulation Promotes Neural Stem Cell Proliferation and Differentiation

作　　者：赵勇亮 安国斌 侯春波 杨瑞瑞 ZHAO Yongliang;AN Guobin;HOU Chunbo;YANG Ruirui(College of Clinical and Basic Medical Sciences,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250117,China)

机构地区：[1]山东第一医科大学(山东省医学科学院)临床与基础医学院,山东济南250117

出　　处：《山东第一医科大学（山东省医学科学院）学报》2022年第8期626-630,共5页Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences

基　　金：山东省自然科学基金(ZR2020MC073);山东省大学生创新创业训练计划(S202110439080)。

摘　　要：外源性神经干细胞(neural stem cells,NSC)移植已成为治疗中枢神经损伤的替代疗法,近年来国内外对此进行了一定研究。尽管目前的实验室和临床研究仍缺乏关于低氧阈刺激对NSC保护机制的有效证据,但提示低氧阈刺激是NSC体外扩增的可行手段,有着广阔的实验研究和临床应用前景,可以为临床提供理论基础。基于此,本文对低氧阈刺激对NSC增殖分化的促进作用进行综述。Exogenous neural stem cells(NSC)transplantation has become an alternative to the treatment of central nervous injuries,and this has been studied at home and abroad in recent years.Although the current laboratory and clinical research still lack effective evidence on the NSC protection mechanism of low oxygen threshold stimulation,suggesting that hypoxia threshold stimulation is a feasible approach of NSC in vitro amplification,providing a theoretical basis for clinical,with broad experimental research and clinical application prospects.Based on this,this article reviews the promotion effect of hypoxia threshold stimulation on NSC proliferation and differentiation.

关 键 词：低氧 神经干细胞 低氧诱导因子1 

分 类 号：R338.1[医药卫生—人体生理学]