血清骨硬化蛋白及Dickkopf-1蛋白表达与特发性股骨头坏死进展的相关性  

Study on the correlation between serum Sclerostin,Dickkopf-1 and the progress of idiopathic osteonecrosis of the femoral head

作　　者：陆万里 张坡 周宇 周海洋[1] 王睿[1] LU Wanli;ZHANG Po;ZHOU Yu;ZHOU Haiyang;WANG Rui(Department of Orthopedics,Nanjing Integrated Traditional Chinese and Western Medicine Hospital,The Affiliated to Nanjing University of Chinese Medicine,Nanjing 210014,China)

机构地区：[1]南京中医药大学附属南京市中西医结合医院骨科,江苏南京210014

出　　处：《西部医学》2022年第8期1152-1156,共5页Medical Journal of West China

基　　金：南京市科技发展计划项目(201605057)。

摘　　要：目的探讨血清骨硬化蛋白(SOST)、Dickkopf-1(Dkk-1)蛋白与特发性股骨头坏死进展的相关性及临床意义。方法纳入2017年1月~2020年6月于我院住院的特发性股骨头坏死患者76例作为观察组。同期选择76例性别、年龄(±1岁)、BMI(±1 kg/m^(2))与观察组配对的健康体检者作为对照组。检测两组血清SOST及Dkk-1蛋白水平并进行分析。结果股骨头坏死患者血清SOST、Dkk-1蛋白水平显著高于对照组(P<0.05)。股骨头坏死患者血清Dkk-1蛋白表达与股骨头坏死ARCO分期呈正相关(r=0.341,P=0.003)。血清SOST与Dkk-1蛋白水平呈正相关(P<0.05)。ROC曲线分析示,血清SOST诊断股骨头坏死敏感性为51.30%,特异性为70.05%;血清Dkk-1诊断股骨头坏死敏感性为80.30%,特异性为63.90%(P<0.05)。结论血清SOST、Dkk-1水平与病程进展密切相关,可作为预测股骨头坏死发生发展的重要指标及潜在的药物治疗靶点。Objective To explore the correlation and clinical significance of the serum Sclerostin(SOST)and Dickkopf-1(Dkk-1)in the progression of idiopathic osteonecrosis of the femoral head(IONFH).Methods 76 patients with idiopathic ONFH admitted to the Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine from January 2017 to June 2020 were included as the experimental group.Meantime,healthy people with sex,age(±1 year)and BMI(±1 kg/m^(2))matched with the experimental group were selected as the control group(n=76).Blood samples were collected from fasting vein to detect and analyze the serum SOST and Dkk-1 levels.Results The serum SOST concentration of patients with ONFH was 1.75(1.09-2.36)ng/mL,which was significantly higher than the control group 1.42(0.66-1.87)ng/mL,P=0.001.The serum Dkk-1 concentration of patients with ONFH was 2.87(2.03-3.64)ng/mL,significantly higher than the control group 1.86(1.17-2.41)ng/mL,P=0.000,the difference was statistically significant.The expression of serum Dkk-1 in patients with ONFH was positively correlated with the ARCO stage of ONFH(r=0.341,P=0.003).The expression of serum SOST and Dkk-1 was positively correlated(P<0.05).ROC curve analysis showed that the sensitivity of serum SOST in the diagnosis of ONFH was 51.30%,and the specificity was 70.05%.The sensitivity of serum Dkk-1 in the diagnosis of ONFH was 80.30%,and the specificity was 63.90%(P<0.05).Conclusion The serum SOST and Dkk-1 play an important role in the occurrence and development of ONFH,and are closely related to the progression of the disease.They might be an important indicators for predicting the occurrence and development of ONFH and potential targets for the treatment of ONFH.

关 键 词：特发性股骨头坏死 骨硬化蛋白 DICKKOPF-1 经典Wnt信号通路 

分 类 号：R604[医药卫生—外科学] R681.3[医药卫生—临床医学]