老年子宫肌瘤腹腔镜切除术采取静吸复合麻醉与单纯静脉麻醉对认知功能及应激指标的影响  

Effects of intravenous inhalation combined anesthesia and simple intravenous anesthesia on cognitive function and stress indicators in laparoscopic myomectomy in the elderly

作　　者：邬胜杰 WU Sheng-jie(Operation Room,Xingning Maternal and Child Health and Family Planning Service Center,Xingning 514500,China)

机构地区：[1]广东省兴宁市妇幼保健计划生育服务中心手术室,514500

出　　处：《中国实用医药》2022年第16期61-64,共4页China Practical Medicine

摘　　要：目的探讨老年子宫肌瘤腹腔镜切除术中采用静吸复合麻醉与单纯静脉麻醉对患者认知功能及应激指标的影响。方法42例行腹腔镜切除术的老年子宫肌瘤患者,按照随机数字表法分为观察组和对照组,每组21例。对照组给予单纯静脉麻醉,观察组给予静吸复合麻醉。比较两组患者生命体征、认知功能及应激指标水平。结果术后30 min,观察组心率(HR)、平均动脉压(MAP)明显低于本组术前,对照组明显高于本组术前,且观察组HR(70.53±8.65)次/min、MAP(90.46±6.45)mm Hg(1 mm Hg=0.133 kPa)明显低于对照组的(94.79±6.92)次/min、(119.77±11.85)mm Hg,差异具有统计学意义(P<0.05)。术后12 h,对照组简易智力状态检查量表(MMSE)评分较本组术前明显下降,差异具有统计学意义(P<0.05);观察组MMSE评分(27.88±4.35)分明显高于对照组的(25.27±3.48)分,差异具有统计学意义(P<0.05)。术后24 h,两组超氧化物歧化酶(SOD)水平较术前明显提高,丙二醛(MDA)水平较术前明显降低,且观察组SOD(27.84±4.52)U/L高于对照组的(21.69±4.15)U/L,MDA(23.72±4.24)nmol/ml低于对照组的(32.65±5.13)nmol/ml,差异具有统计学意义(P<0.05)。结论在老年子宫肌瘤腹腔镜切除术中采用静吸复合麻醉可有效维持患者生命体征稳定,改善应激指标水平,对认知功能的影响较小。Objective To discuss the effects of intravenous inhalation combined anesthesia and simple intravenous anesthesia on cognitive function and stress indicators in laparoscopic myomectomy in the elderly.Methods A total of 42 elderly patients with laparoscopic myomectomy were divided into observation group and control group according to the random numerical table,with 21 cases in each group.The control group received simple intravenous anesthesia,and the observation group received intravenous inhalation combined anesthesia.The vital signs,cognitive function and stress index levels of the two groups were compared.Results At 30 min after surgery,the heart rate(HR)and mean arterial pressure(MAP)of the observation group were significantly lower than those of this group before surgery,and those of the control group were significantly higher than those of this group before surgery;the HR(70.53±8.65)times/min and MAP(90.46±6.45)mm Hg(1 mm Hg=0.133 kPa)in the observation group were significantly lower than(94.79±6.92)times/min and(119.77±11.85)mm Hg in the control group;all the differences were statistically significant(P<0.05).At 12 h after surgery,the mini-mental state examination(MMSE)score in the control group was significantly lower than that of this group before surgery,and the difference was statistically significant(P<0.05).The MMSE score(27.88±4.35)points of the observation group was significantly higher than(25.27±3.48)points of the control group,and the difference was statistically significant(P<0.05).At 24 h after surgery,the levels of superoxide dismutase(SOD)in the two groups were significantly higher than those of this group before surgery;the SOD(27.84±4.52)U/L of the observation group was higher than(21.69±4.15)U/L of the control group,and the MDA(23.72±4.24)nmol/ml was lower than(32.65±5.13)nmol/ml of the control group.All the differences were statistically significant(P<0.05).Conclusion The use of intravenous inhalation combined anesthesia in laparoscopic myomectomy in the elderly can effectively

关 键 词：老年子宫肌瘤 腹腔镜切除术 静吸复合麻醉 单纯静脉麻醉 认知功能 应激指标 

分 类 号：R614[医药卫生—麻醉学]