血管紧张素转化酶抑制剂治疗冠心病的效果探讨  

Effect of angiotensin-converting enzyme inhibitor on coronary heart disease

作　　者：周丹华 ZHOU Dan-hua(Department of Cardiovascular Medicine,Macheng People's Hospital,Macheng 438300,China)

机构地区：[1]麻城市人民医院心血管内科,438300

出　　处：《中国实用医药》2022年第16期128-130,共3页China Practical Medicine

摘　　要：目的探讨血管紧张素转化酶抑制剂治疗冠心病的临床效果。方法120例冠心病患者,通过交替分组方式分为参照组和探析组,各60例。参照组患者应用常规方案进行治疗,探析组患者选择血管紧张素转化酶抑制剂进行治疗。对比两组患者治疗效果、日常生活质量评分及治疗前后脑钠肽水平。结果探析组患者治疗总有效率98.33%高于参照组的83.33%,差异具有统计学意义(P<0.05)。治疗前,两组患者脑钠肽水平比较差异无统计学意义(P>0.05);治疗后,探析组脑钠肽水平(166.54±4.03)pg/ml低于参照组的(200.54±5.65)pg/ml,差异具有统计学意义(P<0.05)。探析组生理机能、生理职能、躯体疼痛、一般健康状况、精力、社会功能、情感职能、精神健康评分分别为(92.32±5.22)、(92.87±5.30)、(92.92±5.32)、(92.95±5.35)、(92.99±5.40)、(93.00±5.42)、(92.98±5.50)、(93.05±5.65)分,均高于参照组的(84.33±3.34)、(84.65±3.40)、(85.00±3.60)、(85.11±3.67)、(85.17±3.72)、(85.18±3.75)、(85.21±3.82)、(85.25±3.92)分,差异具有统计学意义(P<0.05)。结论对冠心病患者实施血管紧张素转化酶抑制剂治疗效果确切,可有效改善患者脑钠肽水平及日常生活质量,值得在临床中进一步推广。Objective To discuss the clinical effect of angiotensin converting enzyme inhibitor on coronary heart disease.Methods A total of 120 patients with coronary heart disease were divided into reference group and analysis group by alternate grouping,with 60 cases in each group.Patients in the reference group were treated with conventional regimens,and patients in the analysis group were treated with angiotensin-converting enzyme inhibitors.The therapeutic effect,quality of daily life scores,and brain natriuretic peptide levels before and after treatment were compared between the two groups.Results The total effective rate 98.33%in the analysis group was higher than 83.33%in the reference group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the level of brain natriuretic peptide between the two groups(P>0.05).After treatment,the level of BNP(166.54±4.03)pg/ml in the analysis group was lower than(200.54±5.65)pg/ml in the reference group,and the difference was statistically significant(P<0.05).The scores of physiological function,role-physical,physical pain,general health,energy,social function,emotional function,and mental health of the analysis group were(92.32±5.22),(92.87±5.30),(92.92±5.32),(92.95±5.35),(92.99±5.40),(93.00±5.42),(92.98±5.50),and(93.05±5.65)points,which were higher than(84.33±3.34),(84.65±3.40),(85.00±3.60),(85.11±3.67),(85.17±3.72),(85.18±3.75),(85.21±3.82),and(85.25±3.92)points of the reference group,and the differences were statistically significant(P<0.05).Conclusion Angiotensin-converting enzyme inhibitor has definite effect on patients with coronary heart disease and can effectively improve the level of brain natriuretic peptide and the quality of daily life of patients,which is worthy of further promotion in clinical practice.

关 键 词：血管紧张素转化酶抑制剂 冠心病 脑钠肽 缺血性心脏病 

分 类 号：R541.4[医药卫生—心血管疾病]