硒酵母联合左旋甲状腺素治疗淋巴细胞性甲状腺炎的临床效果观察  

Clinical effects of selenium yeast combined with levothyroxine in the treatment of lymphoeytic thyroiditis

作　　者：李书华 吴燕平 石辉进 LI Shu-hua;WU Yan-ping;SHI Hui-jin(Child Care Department,Meizhou Women and Children's Hospital,Meizhou 514000,China)

机构地区：[1]梅州市妇幼保健院,梅州市妇女儿童医院,514000

出　　处：《中国实用医药》2022年第16期151-153,共3页China Practical Medicine

基　　金：2017年梅州市社会发展科技计划项目(项目编号:2017B074)项目名称:硒酵母对慢性淋巴细胞性甲状腺炎患者甲状腺过氧化物酶抗体滴度的影响。

摘　　要：目的探究硒酵母联合左旋甲状腺素治疗淋巴细胞性甲状腺炎的临床效果。方法70例淋巴细胞性甲状腺炎患者,依据随机数字表法分为观察组与对照组,每组35例。对照组给予左旋甲状腺素治疗,观察组给予左旋甲状腺素联合硒酵母治疗。比较两组甲状腺自身抗体[甲状腺球蛋白抗体(TGAb)和甲状腺过氧化物酶抗体(TPOAb)]水平、治疗前后患者甲状腺功能指标[游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))、促甲状腺激素(TSH)]、治疗效果、不良反应发生情况。结果治疗后,观察组TGAb、TPOAb水平分别为(65.92±7.91)、(125.12±11.21)U/ml,均低于对照组的(87.21±8.21)、(213.82±10.71)U/ml,差异有统计学意义(P<0.05)。治疗后,两组FT_(3)、FT_(4)、TSH水平均优于本组治疗前,且观察组FT_(3)、FT_(4)、TSH水平分别为(5.12±1.21)pmoL/L、(16.56±3.21)pmoL/L、(5.19±0.21)mU/L,均优于对照组的(3.56±1.01)pmoL/L、(12.56±2.31)pmoL/L、(7.21±0.67)mU/L,差异均有统计学意义(P<0.05)。观察组治疗总有效率94.29%高于对照组的74.29%,差异有统计学意义(P<0.05)。两组治疗过程中均未发生不良反应。结论左旋甲状腺素联合硒酵母对于淋巴细胞性甲状腺炎的治疗效果确切,可更好改善患者甲状腺功能和自身抗体水平,安全性高,值得推广和应用。Objective To investigate the Clinical effects of selenium yeast combined with levothyroxine in the treatment of lymphoeytic thyroiditis.Methods 70 patients with lymphocytic thyroiditis were randomly divided into an observation group and a control group,with 35 cases in each group.Patients in the control group were administered with levothyroxine,and patients in the observation group were administered with levothyroxine combined with selenium yeast.The levels of thyroid autoantibody[thyroglobulin antibody(TGAb)and thyroid peroxidase antibody(TPOAb)],thyroid function indexes[free triiodothyronine(FT_(3)),free thyroxine(FT_(4)),thyroid stimulating hormone(TSH)]before and after treatment,treatment effects and adverse reactions were compared between the two groups.Results After treatment,the observation group had TGAb level of(65.92±7.91)U/ml and TPOAb level of(125.12±11.21)U/ml,which were lower than(87.21±8.21)U/ml and(213.82±10.71)U/ml of the control group,respectively,and the differences were statistically significant(P<0.05).After the treatment,the levels of FT_(3),FT_(4) and TSH of the two groups were better than those of this group before the treatment.In addition,the levels of FT_(3),FT_(4) and TSH of the observation group were(5.12±1.21)pmol/L,(16.56±3.21)pmol/L and(5.19±0.21)mU/L,respectively,which were better than(3.56±1.01)pmol/L,(12.56±2.31)pmol/L and(7.21±0.67)mU/L of the control group,respectively,and the differences were statistically significant(P<0.05).The overall efficacy of the observation group was 94.29%,which was higher than 74.29%of the control group,and the difference was statistically significant(P<0.05).No adverse reactions occurred in either group during treatment.Conclusion Levothyroxine combined with selenium yeast is significantly effective in the treatment of lymphocytic thyroiditis.It can improve the thyroid function and autoantibody level of patients,with high safety.Therefore,Thus,it is worth promoting and employing.

关 键 词：淋巴细胞性甲状腺炎 硒酵母 左旋甲状腺素 临床效果 

分 类 号：R581.4[医药卫生—内分泌]