甘草酸苷治疗神经系统受累期手足口病患儿的临床研究  

Clinical study of glycyrrhizin in the treatment of children with hand-foot-mouth disease at the stage of nervous system involvement

作　　者：邓少芳 凌静冬 李彬 叶潇鸣 罗杰平 陈丽珍 黄胜贤 DENG Shaofang;LING Jingdong;LI Bin;YE Xiaoming;LUO Jieping;CHEN Lizhen;HUANG Shengxian(Department of Medical Laboratory,the Third Affiliated Hospital of Guangxi Medical University/the Second Nanning People's Hospital,Nanning,Guangxi 530031,China;Department of Pediatrics,the Third Affiliated Hospital of Guangxi Medical University/the Second Nanning People's Hospital,Nanning,Guangxi 530031,China)

机构地区：[1]广西医科大学第三附属医院暨南宁市第二人民医院医学检验科,广西南宁530031 [2]广西医科大学第三附属医院暨南宁市第二人民医院儿科,广西南宁530031

出　　处：《现代医药卫生》2022年第16期2701-2704,共4页Journal of Modern Medicine & Health

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(Z20170116)。

摘　　要：目的探讨甘草酸苷治疗神经系统受累期手足口病(HFMD)患儿的临床疗效。方法选取2017年1月至2019年10月该院神经系统受累期HFMD患儿138例,根据随机数字表法分为常规治疗组(66例)和研究组(72例),同时选取健康体检儿童作为对照组(63例)。比较3组免疫细胞、免疫球蛋白、炎性细胞因子水平,同时对常规治疗组和研究组临床疗效进行分析。结果常规治疗组、研究组退热起效时间、恢复正常体温时间、皮疹消失时间、精神状态恢复情况或惊颤消失时间及临床疗效比较,差异有统计学意义(P<0.05)。对照组与常规治疗组免疫功能相关指标比较,差异有统计学意义(P<0.05)。对照组与研究组免疫功能相关指标(除细胞毒性T细胞、自然杀伤细胞、B淋巴细胞外)比较,差异有统计学意义(P<0.05)。常规治疗组与研究组免疫功能相关指标(除细胞毒性T细胞、自然杀伤细胞外)比较,差异有统计学意义(P<0.05)。免疫球蛋白M水平与B淋巴细胞水平呈正相关(r=0.852,P=0.016)。结论甘草酸苷可有效改善神经系统受累期HFMD患儿临床症状和免疫功能紊乱,具有较好的临床治疗效果。Objective To investigate the clinical efficacy of glycyrrhizin in the treatment of children with hand-foot-mouth disease(HFMD)at the stage of nervous system involvement.Methods A total of 138 children with HFMD at the stage of nervous system involvement in this hospital from January 2017 to October 2019 were selected and divided into the conventional treatment group(66 cases)and the study group(72 cases)according to the random number table method.At the same time,healthy physically examined children were selected as the control group(63 cases).The levels of immune cells,immunoglobulins and inflammatory cytokines in the three groups were compared,and the clinical efficacy of the conventional treatment group and the study group were analyzed.Results There were significant differences between the conventional treatment group and the study group in the onset time of antipyretic effect,the time of recovery of normal body temperature,the time of disappearance of rash,the time of recovery of mental state or the time of disappearance of tremor and clinical efficacy(P<0.05).There were significant differences in the related indexes of immune function between the control group and the conventional treatment group(P<0.05).There were significant differences in the related indexes of immune function(except Tc cells,NK cells and B lymphocytes)between the control group and the study group(P<0.05).There were significant differences in immune function related indexes(except Tc cells and NK cells)between the conventional treatment group and the study group(P<0.05).IgM level was positively correlated with B lymphocyte level(r=0.852,P=0.016).Conclu-sion Glycyrrhizin can effectively improve the clinical symptoms and immune dysfunction of children with HFMD at the stage of nervous system involvement,and has a good clinical therapeutic effect.

关 键 词：甘草酸苷 手足口病 临床疗效 免疫功能 

分 类 号：R725.1[医药卫生—儿科]