T2 mapping定量评价腰椎间盘退变的Meta分析  

The value of quantitative assessment of lumbar disc degeneration with T2 mapping: A Meta analysis

作　　者：张旭胤 郭银霞[1] PAXON Julien Michael ABDETA Bogale Girma 杜永浩[1] 牛刚[1] ZHANG Xuyin;GUO Yinxia;PAXON Julien Michael;ABDETA Bogale Girma;DU Yonghao;NIU Gang(Department of Radiology,First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院影像科,西安710061

出　　处：《磁共振成像》2022年第8期55-59,70,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：陕西省重点研发计划一般项目(编号:2020SF-104)。

摘　　要：目的利用Meta分析定量评估腰椎间盘退变髓核横向弛豫时间的变化规律。材料与方法检索自建库至2021年10月31日采用T2 mapping方法定量评估腰椎间盘退变的文献,英文数据库检索Cochrane Library、PubMed、EMBASE,中文数据库检索万方数据、维普网、中国知网。采用RevMan 5.3和Stata 15.0软件计算不同等级腰椎间盘退变间髓核横向弛豫时间的加权均数差值(weighted mean difference,WMD)及其95%可信区间(confidential interval,CI)。结果共纳入文献13篇,包括Ⅰ级腰椎间盘362个,Ⅱ级腰椎间盘1418个,Ⅲ级腰椎间盘1006个,Ⅳ级腰椎间盘548个,Ⅴ级腰椎间盘201个。腰椎间盘髓核横向弛豫时间随着腰椎间盘退变等级的增加而逐渐下降。Ⅰ级横向弛豫时间明显高于Ⅱ级横向弛豫时间(WMD=35.58,95%CI:29.96~41.21,P<0.01),Ⅱ级横向弛豫时间明显高于Ⅲ级横向弛豫时间(WMD=32.93,95%CI:25.61~40.25,P<0.01),Ⅲ级横向弛豫时间明显高于Ⅳ级横向弛豫时间(WMD=26.52,95%CI:20.88~32.15,P<0.01),Ⅳ级横向弛豫时间高于Ⅴ级横向弛豫时间(WMD=4.23,95%CI:2.00~6.46,P<0.01)。结论髓核横向弛豫时间能够区分腰椎间盘不同程度的退变,T2 mapping可作为辅助诊断腰椎间盘早期退变的影像学检查。Objective: To quantitatively evaluate the changes in nucleus pulposus T2 relaxation time of lumbar disc degeneration using Meta analysis. Materials and Methods: Retrieved the literatures from the library construction to October 31 2021 published in the Cochrane Library, PubMed, EMBASE, Wanfang Data, CQVIP, China National Knowledge Infrastructure(CNKI) databases applying T2mapping method to assess lumbar disc degeneration. RevMan 5.3 and Stata1 5.0 softwares were used to calculate the weighted mean difference(WMD) and 95% confidential interval(CI) of the T2 relaxation time of nucleus pulposus between different gardes of lumbar disc degeneration. Results: Thirteen articles were included, inlcuding 362 grade Ⅰ lumbar intervertebral discs, 1418 grade Ⅱ lumbar intervertebral discs, 1006 grade Ⅲ lumbar intervertebral discs, 548 grade Ⅳ lumbar intervertebral discs, and 201 grade Ⅴ lumbar intervertebral discs. The T2 relaxation time of the lumbar intervertebral disc nucleus pulposus gradually decreased with the increase of the lumbar intervertebral disc grade. The grade Ⅰ T2 relaxation time is significantly higher than the grade Ⅱ T2 relaxation time(WMD=35.58, 95% CI: 29.96-41.21, P<0.01), and the grade Ⅱ T2 relaxation time is significantly higher than the grade Ⅲ T2 relaxation time(WMD=32.93, 95% CI: 25.61-40.25, P<0.01), the grade Ⅲ T2 relaxation time is significantly higher than the grade Ⅳ T2 relaxation time(WMD=26.52, 95% CI: 20.88-32.15, P<0.01), the grade Ⅳ T2 relaxation time is higher than the grade Ⅴ(WMD=4.23, 95% CI:2.00-6.46, P<0.01). Conclusions: The T2 relaxation time of the nucleus pulposus can distinguish different degrees of degeneration of the lumbar intervertebral disc. T2 mapping can be used as an imaging examination to assist in the diagnosis of early degeneration of the lumbar intervertebral disc.

关 键 词：T2 mapping 横向弛豫时间 磁共振成像 腰椎 椎间盘退变 META分析 

分 类 号：R445.2[医药卫生—影像医学与核医学] R681.53[医药卫生—诊断学]