磁共振脑功能成像在青少年抑郁症中的研究进展  

Research progress of magnetic resonance functional brain imaging in adolescent depression

作　　者：邓杰 何建波 邱丽华 DENG Jie;HE Jianbo;QIU Lihua(Department of Radiology,the Affiliated Hospital of Southwest Medical University,Luzhou 646000,China;Department of Radiology,the Fourth People's Hospital of Yibin,Yibin 644000,China;Neurographic Big Data Research Center,Clinical Research and Translational Center,Second People's Hospital of Yibin City-West China Yibin Hospital,Sichuan University,Yibin 644000,China.)

机构地区：[1]西南医科大学附属医院放射科,泸州646000 [2]宜宾市第四人民医院放射科,宜宾644000 [3]神经影像大数据研究中心,宜宾市第二人民医院·四川大学华西医院宜宾医院临床医学研究与转化中心,宜宾644000

出　　处：《磁共振成像》2022年第8期101-103,108,共4页Chinese Journal of Magnetic Resonance Imaging

基　　金：四川省科技计划项目(编号:2018JY0666);中国博士后科学基金第58批(编号:2015M582554);四川省卫生和计划生育委员会科研课题(编号:150251);功能与分子影像四川省重点实验室开放课题(编号:SCU-HM-2021001);宜宾市卫生健康委员会项目(编号:2020YW085)。

摘　　要：青少年抑郁症因其高发病率、高复发率及高致残率成为社会和临床医生共同关注的问题。随着影像技术的发展,磁共振脑功能成像在成人抑郁症中已有较多研究,而对青少年抑郁症研究较少。近年来青少年抑郁症功能MRI、磁共振波谱及磁共振灌注加权成像研究显示,青少年抑郁症患者额叶—边缘系统、基底神经节、胼胝体及小脑等区域功能、代谢及血流灌注异常,这些脑区与情感、记忆、奖励、认知等功能有关,可能是青少年抑郁症发病的潜在生物标志物。本文简要综述近年来青少年抑郁症磁共振脑功能成像研究结果及潜在不足,旨在为今后的研究提供方向。Due to the high incidence, recurrence and disability rats, adolescent depression has become a common concern of society and clinicians. With the development of imaging technology, functional magnetic resonance imaging(fMRI) has been widely used in the research of adult depression, but few studies on adolescent depression. In recent years, the results of fMRI, magnetic resonance spectroscopy and MR perfusion weighted imaging show that the frontal-limbic system, basal ganglia, corpus callosum, cerebellum and other regions of adolescent depression are abnormal in function, metabolism and blood perfusion. These regions are associated with emotion, memory, reward, cognition and other functions, and may be potential biomarkers of adolescent depression. This paper briefly reviews the research results and potential deficiencies of fMRI in adolescent depression in recent years, in order to provide direction for future research.

关 键 词：青少年抑郁症 磁共振成像 磁共振波谱 灌注加权成像 动脉自旋标记 血氧水平依赖 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.4[医药卫生—诊断学]