单纯疱疹病毒型脑炎患者血清AchE、sOX40L水平与认知功能的相关性  

Correlation between serum AchE,sOX40L and cognitive function in patients with herpes simplex virus encephalitis

作　　者：王莎[1] 贺龙 李素婷[1] 王东红[3] 王静[4] WANG Sha;HE Long;LI Suting;WANG Donghong;WANG Jing(Department of NeurologyⅡ,Handan First Hospital,Handan,Hebei 056002,China;Department of NeurosurgeryⅢ,Handan Central Hospital,Handan,Hebei 056002,China;Department of Blood Transfusion,Handan Central Hospital,Handan,Hebei 056002,China;CT Room,Handan First Hospital,Handan,Hebei 056002,China)

机构地区：[1]邯郸市第一医院神经内二科,河北邯郸056002 [2]邯郸市中心医院神经外三科,河北邯郸056002 [3]邯郸市中心医院输血科,河北邯郸056002 [4]邯郸市第一医院CT室,河北邯郸056002

出　　处：《国际检验医学杂志》2022年第16期1989-1993,共5页International Journal of Laboratory Medicine

基　　金：河北省2020年度医学科学研究课题(20200439)。

摘　　要：目的观察单纯疱疹病毒型脑炎(HSE)患者血清乙酰胆碱酯酶(AchE)、可溶性OX40L(sOX40L)水平及认知功能变化情况,探讨血清AchE、sOX40L水平与认知功能关系。方法选取2017年3月至2020年12月邯郸市第一医院收治的HSE患者63例作为观察组,同期体检健康者63例作为对照组。比较两组血清AchE、sOX40L水平、认知功能[简易精神状态检查量表(MMSE)评分],分析血清AchE、sOX40L水平与MMSE评分的关系,以及HSE患者认知功能的影响因素。结果观察组血清AchE、sOX40L水平高于对照组,MMSE评分低于对照组,差异均有统计学意义(P<0.05),随着MMSE评分降低,血清AchE、sOX40L水平呈升高趋势;血清AchE、sOX40L水平与MMSE评分呈负相关(r=-0.675、-0.598,均P<0.001);多元线性逐步回归分析显示,校正白细胞介素6、C反应蛋白水平后,AchE、sOX40L、癫痫发作仍是认知功能损害的影响因素(P<0.05)。结论HSE患者血清AchE、sOX40L水平异常,其血清AchE、sOX40L水平与患者认知功能有关。Objective To observe the serum acetylcholinesterase(AchE),soluble OX40 L(sOX40 L)levels and changes of cognitive function in patients with herpes simplex virus encephalitis(HSE),and to explore the relationship between serum AchE,sOX40 L levels and cognitive function.Methods A total of 63 HSE in Handan First Hospital from March 2017 to December 2020 were selected as the observation group,and 63 healthy subjects during the same period were selected as the control group.Serum AchE,sOX40 L levels and cognitive function(MMSE score)were compared between the two groups,and the relationship between serum AchE,sOX40 L levels and MMSE score was analyzed,as well as the influencing factors of cognitive function in HSE patients.Results The serum AchE and sOX40 L levels in the observation group were higher than those in the control group,while MMSE score was lower than that in the control group,the differences were statistically significant(P<0.05).With the MMSE score decreasing,the serum AchE and sOX40 L levels showed an increasing trend.Serum AchE and sOX40 L levels were negatively correlated with MMSE score(r=-0.675,-0.598,both P<0.001).Multiple linear stepwise regression analysis showed that AchE,sOX40 L and seizures were still influencing factors of cognitive impairment after adjusting for interleukin-6 and C-reactive protein levels(P<0.05).Conclusion The levels of serum AchE and sOX40 L in patients with HSE are abnormal,and they are closely related to the cognitive function.

关 键 词：单纯疱疹病毒型脑炎 乙酰胆碱酯酶 可溶性OX40L 认知功能 相关性 

分 类 号：R512.3[医药卫生—内科学]