多功能复方溶致液晶治疗5 Gyγ射线照射小鼠皮肤损伤  

Multifunctional compound lyotropic liquid crystals for the treatment of skin wounds induced by 5 Gy gamma irradiation in mouse

作　　者：夏明宇 胡静璐 曹祥龙 王辰允[3] 杜丽娜 金义光 XIA Mingyu;HU Jinglu;CAO Xianglong;WANG Chenyun;DU Lina;JIN Yiguang(Beijing Institute of Radiation Medicine,Beijing 100850,China;Pharmaceutical College of Henan University,Kaifeng 475004,China;The Fourth Clinical Center Affiliated to Chinese PLA General Hospital,Beijing 100048,China)

机构地区：[1]军事科学院军事医学研究院辐射医学研究所,北京100850 [2]河南大学药学院,开封475004 [3]解放军总医院第四医学中心卫勤部,北京100048

出　　处：《辐射研究与辐射工艺学报》2022年第4期11-18,共8页Journal of Radiation Research and Radiation Processing

基　　金：总后青年培育项目(14QNP103)资助。

摘　　要：制备多功能复方溶致液晶并实现治疗5 Gy γ射线照射小鼠皮肤损伤。以单油酸甘油酯(GMO)和泊洛沙姆407为基质制备多功能载药溶致液晶,包括促愈合的芦荟提取物、抗菌的茶树油、镇痛的盐酸利多卡因。建立5 Gy γ射线照射小鼠皮肤损伤模型,以创面愈合率、苏木精-伊红染色和Masson染色病理结果为指标,评价多功能复方溶致液晶对受照小鼠皮肤损伤的促愈合效果。结果表明,质量浓度为0.2 g/mL的泊洛沙姆407、质量浓度为0.4 g/mL的GMO制备而成的多功能复方溶致液晶黏度较大,局部滞留时间长,利于持续释药。在体小鼠实验结果表明,多功能复方溶致液晶能明显加快受照小鼠损伤皮肤的伤口愈合速度,伤口愈合率于第14日达90%以上。多功能复方溶致液晶为治疗γ射线照射小鼠皮肤损伤提供一种新选择。To evaluate the therapeutic effect of the lyotropic liquid crystals on mice skin wounds with 5 Gy γirradiation, including alleviation of pain, promotion of wound healing and inhibition of bacterial growth. Crystals were prepared with aloe extract to promote wound healing, tea tree oil to inhibit bacterial growth, and lidocaine hydrochloride to relieve pain. Glyceryl monooleate(GMO) and poloxamer 407 were used as matrice. The therapeutic effect of the crystals on radiation-induced skin wounds were evaluated based on wound healing rate and staining with hematoxylin and eosin stain and Masson’s trichrome stain. Crystals prepared with 0.2 g/mL poloxamer407 and 0.4 g/mL GMO displayed pronounced viscosity with long residence time on skin when applied topically.The formulation enabled consistent drug release and promoted the rate of wound healing which exceeded 90%within 14 days. The novel multifunctional lyotropic liquid crystal could be efficient in treating skin wounds caused by γ irradiation.

关 键 词：溶致液晶 辐照 皮肤损伤 镇痛 抗菌 

分 类 号：R943[医药卫生—药剂学]