社区获得性肺炎Ang-2、suPAR的表达及其预后预测价值  

Expression of Ang-2 and suPAR in community-acquired pneumonia and its prognostic value

作　　者：刘则林 苗雅娇 门猛 Liu Zelin;Miao Yajiao;Men Meng(Department of Medical Administration,Langfang People's Hospital,Langfang 065000,China;Department of Infection,Langfang Peopled Hospital,Langfiing 065000,China)

机构地区：[1]廊坊市人民医院医务部,廊坊065000 [2]廊坊市人民医院感染科,廊坊065000

出　　处：《国际呼吸杂志》2022年第14期1047-1051,共5页International Journal of Respiration

基　　金：廊坊市科技支撑计划项目(2020013080)。

摘　　要：目的分析外周血血管生成素2(Ang-2)、可溶型尿激酶型纤溶酶原激活物受体(suPAR)水平与社区获得性肺炎(CAP)严重程度和预后的关系及其预测患者预后生存的价值。方法本研究为病例对照研究。采用随机抽样法选取2015年1月到2019年12月廊坊市人民医院收治的296例CAP患者。根据英国胸科协会改良肺炎(CURB-65)评分将CAP患者分为低危组113例、中危组103例、高危组80例。根据预后结局分为生存组230例、死亡组66例。比较各组CURB-65评分、Ang-2、suPAR水平,采用受试者工作特征曲线分析其预后预测价值。结果单因素方差分析显示,3组CURB-65评分、suPAR、Ang-2水平之间比较差异均有统计学意义,且高危组高于中危组,中危组高于低危组(P值均<0.05);死亡组患者的CURB-65评分、suPAR、Ang-2水平均高于生存组(P值均<0.05);Ang-2、suPAR与CURB-65评分均呈正相关(r值分别为0.64、0.67,P值均<0.05);受试者工作特征曲线分析显示,Ang-2、suPAR及其联合预测CAP预后生存的曲线下面积分别为0.86、0.87、0.90,敏感度分别为71.20%、72.70%、95.50%,特异度分别为87.80%、87.80%、89.10%。结论外周血Ang-2、suPAR水平越高,CAP严重程度越重,CAP患者死亡风险越高。Ang-2、suPAR及其联合具有较高的CAP预后生存预测价值。Objective To explore the relationship between the levels of peripheral blood angiopoietin-2(Ang-2),soluble urokinase-type plasminogen activator receptor(suPAR)and the severity,prognosis of community-acquired pneumonia(CAP),and to analyze its value in assessing the prognostic survival of patients.Methods A case-control study was performed.A total of 296 CAP patients admitted to Langfang People's Hospital from January 2015 to December 2019 were selected by random sampling method.According to the British Thoracic Society Modified Pneumonia(CURB-65)score,the patients were divided into low-risk groups(113 cases),intermediate-risk group(103 cases),and high-risk group(80 cases).According to the prognosis,the patients were divided into survival group(230 cases)and death group(66 cases).CURB-65 score,the levels of Ang-2 and suPAR were compared between the groups,and subject operating characteristic curve was employed to analyze its prognostic value.Results One-way analysis of variance showed that there were statistical differences between the three groups of CURB-65 score,suPAR level,and Ang-2 level,with the high-risk group higher than the intermediate-risk group and the intermediate-risk group higher than the low-risk group(all P<0.0.05).The CURB-65 score,suPAR and Ang-2 levels of the death group were higher than those of the survival group(all P V 0.05).Ang-2,suPAR and CURB-65 score were positively correlated(r values were 0.64 and 0.67,respectively,both P<0.05).ROC curve analysis showed that the AUC of Ang-2,suPAR and their combination to assess the prognosis of CAP was 0.86,0.87,and 0.90,respectively,and the sensitivity was respectively 71.20%,72.70%,and 95.50%,and the specificity 87.80%,87.80%,and 89.10%.Conclusions The higher the level of Ang-2 and suPAR in peripheral blood,the more severe the CAP.The higher the level of Ang-2 and suPAR,the higher the risk of death in CAP patients.Ang-2,suPAR and the combination have a relatively high evaluation value of prognostic survival for CAP.

关 键 词：社区获得性肺炎 预后 血管生成素2 可溶型尿激酶型纤溶酶原激活物受体 严重程度 

分 类 号：R563.1[医药卫生—呼吸系统]