小儿法罗培南钠对儿童呼吸道常见致病菌的体外抗菌活性研究  

In vitro antibacterial activity of pediatric Faropenem sodium against respiratory tract pathogens in children

作　　者：董立民 袁林 高薇 王青 史伟 李玥 于丹 孟庆红 刘钢[2] 姚开虎 Dong Limin;Yuan Lin;Gao Wei;Wang Qing;Shi Wei;Li Yue;Yu Dan;Meng Qinghong;Liu Gang;Yao Kaihu(Key Laboratory of Major Diseases in Children,Ministry of Education,National Key Discipline of Pediatrics(Capital Medical University),Laboratory of Dermatology,Beijing Pediatric Research Institute,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China;Department of Infectious Disease,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing 100045,China)

机构地区：[1]国家儿童医学中心,首都医科大学附属北京儿童医院,北京市儿科研究所皮肤疾病研究室,国家呼吸系统疾病临床医学研究中心,教育部儿科重大疾病研究重点实验室,北京100045 [2]国家儿童医学中心,首都医科大学附属北京儿童医院感染科,北京100045

出　　处：《中华实用儿科临床杂志》2022年第14期1086-1092,共7页Chinese Journal of Applied Clinical Pediatrics

基　　金：福棠儿童医学发展研究中心项目(FTCSF-2020-01)。

摘　　要：目的评估小儿法罗培南钠对儿童呼吸道临床分离常见致病菌的体外抗菌活性,为其临床研究和应用提供参考。方法回顾性分析。采用琼脂稀释法测定法罗培南钠、美罗培南、亚胺培南等抗菌药物对儿童临床分离的156株肺炎链球菌[青霉素敏感(PSSP)32株、青霉素中介(PISP)28株及青霉素耐药(PRSP)96株]、98株流感嗜血杆菌、173株肺炎克雷伯菌和55株卡他莫拉菌的最低抑菌浓度(MIC),计算MIC_(50)、MIC_(90)及累积抑菌百分率。结果法罗培南钠对肺炎链球菌的MIC范围为0.010~2.000 mg/L;PSSP、PISP、PRSP的MIC分布无差别,MIC_(90)皆为1.000 mg/L。对流感嗜血杆菌的MIC范围为0.030~8.000 mg/L,其产酶和氨苄西林耐药表型不同的菌株之间比较,MIC分布无明显差别,MIC_(90)皆为4.000 mg/L。对肺炎克雷伯菌的MIC范围为0.250~>32.000 mg/L,MIC_(50)和MIC_(90)均>32.000 mg/L。法罗培南钠对卡他莫拉菌的MIC范围为0.030~2.000 mg/L,MIC_(50)为0.500 mg/L,MIC_(90)为1.000 mg/L。结论体外药敏试验结果表明,小儿法罗培南钠对肺炎链球菌、流感嗜血杆菌、卡他莫拉菌均有较好的抑菌效果,但抑制肺炎克雷伯菌的作用较弱。Objective To evaluate the antibacterial activity of pediatric Faropenem sodium against common pathogens isolated from children′s respiratory tract in vitro,and to provide reference for its clinical research and application.Methods Retrospective analysis.The minimum inhibitory concentration(MIC)of Faropenem sodium,Merope-nem,Imipenem and other antibiotics was determined by the agar dilution method.A total of 156 strains of Streptococcus pneumoniae[including 32 strains of Penicillin-susceptible Streptococcus pneumoniae(PSSP),28 strains of Penicillin-intermediate Streptococcus pneumoniae(PISP)and 96 strains of Penicillin-resistant Streptococcus pneumoniae(PRSP)],98 strains of Haemophilus influenza,173 strains of Klebsiella pneumoniae,and 55 strains of Moraxella catarrhali clinical isolates were used.MIC_(50),MIC_(90) and the accumulative inhibition of the bacteria were investigated.Results The MIC of Faropenem sodium against all the Streptococcus pneumoniae strains ranged from 0.010-2.000 mg/L.There was no difference in the MIC distribution of Faropenem sodium against PSSP,PISP and PRSP,and the MIC_(90) value was all 1.000 mg/L.Faropenem sodium inhibited all the Haemophilus influenza strains at concentrations ranging from 0.030-8.000 mg/L.There was no difference in the MIC distribution of Faropenem sodium against Haemophilus influenza with or withoutβ-lactamase and Ampicillin resistance.The MIC_(90) value was all 4.000 mg/L.Ho-wever,the MIC of Faropenem sodium against Klebsiella pneumoniae ranged from 0.250 to above 32.000 mg/L,and both MIC_(50) and MIC_(90) were greater than 32.000 mg/L.Faropenem sodium inhibited all the Moraxella catarrhalis strains at concentrations ranging from 0.030-2.000 mg/L,with MIC_(50) being 0.500 mg/L and MIC_(90) being 1.000 mg/L.Conclusions Antimicrobial susceptibility testing results in vitro demonstrate that pediatric Faropenem sodium has satisfactory antibacterial activities against Streptococcus pneumoniae,Haemophilus influenza,and Moraxella catarrhalis,but comparatively weak ant

关 键 词：法罗培南钠 呼吸道致病菌 肺炎链球菌 流感嗜血杆菌 肺炎克雷伯菌 卡他莫拉菌 儿童 

分 类 号：R725.6[医药卫生—儿科]