儿童重症呼吸道合胞病毒性肺炎发生闭塞性细支气管炎的危险因素及临床特征分析  

Risk factors of bronchiolitis obliterans in children with severe respiratory syncytial virus pneumonia and analysis of the clinical characteristics

作　　者：邓倩晔 陈超 时晨辉 Deng Qianye;Chen Chao;Shi Chenhui(Department of pediatrics,the eighth people’s hospital of Wuxi,Wuxi,Jiangsu,214100,China)

机构地区：[1]无锡市第八人民医院,江苏无锡214100

出　　处：《齐齐哈尔医学院学报》2022年第12期1154-1157,共4页Journal of Qiqihar Medical University

摘　　要：目的 探讨儿童重症呼吸道合胞病毒性肺炎发生闭塞性细支气管炎(BO)的危险因素及临床特征分析。方法 回顾性分析2019年1月—2021年12月本院收治的72例重症呼吸道合胞病毒性肺炎患儿,按照是否发展为BO分为观察组和对照组两组,每组各36例。比较两组患儿的临床特征,并通过单因素和多因素Logistic回归分析影响重症呼吸道合胞病毒性肺炎发生BO的独立危险因素。结果 两组患者的贫血、住院时间、热峰、呼吸困难、谷草转氨酶、乳酸脱氢酶、降钙素原、肺外并发症消化系统及神经系统、治疗中有创机械通气和机械通气时间比较,差异均有统计学意义(P<0.05)。经单因素、多因素Logistic回归分析显示,热程长、呼吸困难和有创机械通气是重症呼吸道合胞病毒性肺炎发生BO的独立危险因素,差异均有统计学意义(P<0.05)。结论 儿童重症呼吸道合胞病毒性肺炎发生BO具有特殊的临床特征,发热时间较长、出现呼吸困难、需要有创机械通气是儿童重症呼吸道合胞病毒性肺炎发生BO的危险因素,需要对存在BO独立危险因素的患儿进行临床随访,早期识别、治疗BO患儿,从而改善患儿的生活质量。Objective To investigate the risk factors of bronchiolitis obliterans(BO) in children with severe respiratory syncytial virus pneumonia, and analyse the clinical characteristics.Methods 72 children suffered with severe respiratory syncytial virus pneumonia those were admitted to our hospital from January 2019 to December 2021 were enrolled as study objects, and they were divided into observation group and control group according to the occurrence of BO, with 36 cases in each group. The clinical characteristics of the two groups were compared, and the independent risk factors of BO in severe respiratory syncytial virus pneumonia were analyzed by univariate and multivariate logistic regression.Results The occurrence of anemia, time of hospital stay, fever peak, dyspnea, aspartate transaminase, lactate dehydrogenase, procalcitonin, extra-pulmonary complications, digestive system and nervous system, invasive mechanical ventilation and mechanical ventilation during treatment were compared between the two group, the differences were statistically significant(P<0.05). Univariate and multivariate logistic regression analysis showed that long heat course, dyspnea, invasive mechanical ventilation were independent risk factors for BO, the differences were statistically significant(P<0.05).Conclusions BO in children with severe respiratory syncytial virus pneumonia has special clinical characteristics. Long fever time, dyspnea and the need for invasive mechanical ventilation are the risk factors of BO in children with severe respiratory syncytial virus pneumonia. It is necessary to follow up the children with independent risk factors of BO, identify and treat the children with BO early, so as to improve the quality of life of children.

关 键 词：重症呼吸道合胞病毒性肺炎 患儿 闭塞性细支气管炎 临床特征 危险因素 

分 类 号：R725.6[医药卫生—儿科]